DegronMD

Uniprot ID: Q9NYB9

Source protein: Abl interactor 2

Source gene: ABI2

Class: DEG_SPOP_SBC_1

Location: 337:341

E3 ligase: SPOP

DEGRON score: 0.9646

ASA_SCORE: 88.6

COIL: 0.962

CONS_SCORE: 0.3404

DSS_SCORE: 0.6501

HELIX: 0.012

FCONS_SCORE: 1.0452

RIG_SCORE: 0.5907

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q328H	TCGA-CM-5344	COAD	TCGA	VVSST	DEG_SPOP_SBC_1	0.0833
p.Q328H	TCGA-DD-AADR	LIHC	TCGA	VVSST	DEG_SPOP_SBC_1	0.0833
p.Q328H	TCGA-EY-A1G7	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	0.0833
p.Q346K	TCGA-DK-AA6W	BLCA	TCGA	VVSST	DEG_SPOP_SBC_1	0.1944
p.Q346K	DO219009	BLCA	ICGC	VVSST	DEG_SPOP_SBC_1	0.1944
p.V343I	TCGA-EO-A22U	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	0.2778
p.V343I	DO43755	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	0.2778
p.P330A	TCGA-SX-A7SL	KIRP	TCGA	VVSST	DEG_SPOP_SBC_1	0.1389
p.D345H	DO51859	BLCA	ICGC	VVSST	DEG_SPOP_SBC_1	0.2222
p.Q340H	DO10252	COAD	ICGC	VVSST	DEG_SPOP_SBC_1	0.7582
p.Q340H	DO52245	LIHC	ICGC	VVSST	DEG_SPOP_SBC_1	0.7582
p.Q340H	DO41223	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	0.7582
p.P336H	DO10880	GBM	ICGC	VVSST	DEG_SPOP_SBC_1	0.3056
p.P342H	DO17323	KIRC	ICGC	VVSST	DEG_SPOP_SBC_1	0.3056
p.D345Y	DO16696	KIRC	ICGC	VVSST	DEG_SPOP_SBC_1	0.2222
p.P342A	DO49783	KIRP	ICGC	VVSST	DEG_SPOP_SBC_1	0.3056
p.A334S	DO229038	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.25
p.L341I	SIDM01259	B-Lymphoblastic Leukemia	GDSC	VVSST	DEG_SPOP_SBC_1	0.7174
p.L341I	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	0.7174
p.P335T	SIDM00917	Acute Myeloid Leukemia	GDSC	VVSST	DEG_SPOP_SBC_1	0.2778
p.P335T	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	0.2778
p.P347L	SIDM00429	B-Lymphoblastic Leukemia	GDSC	VVSST	DEG_SPOP_SBC_1	0.1667
p.P347L	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	0.1667
p.D328Y	SIDM00920	Breast Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	0.0833
p.D328Y	CAMA-1	breast	COSMIC	VVSST	DEG_SPOP_SBC_1	0.0833
p.T331A	ACH-000881	Skin Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.1667
p.T331A	MEL-JUSO	skin	COSMIC	VVSST	DEG_SPOP_SBC_1	0.1667
p.L328H	SF295	central_nervous_system	COSMIC	VVSST	DEG_SPOP_SBC_1	0.0833
p.P341L	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	0.7582
p.L350H	SF295	central_nervous_system	COSMIC	VVSST	DEG_SPOP_SBC_1	0.0833
p.V334A	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	0.25
p.P329T	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	184:188	VVSST	SPOP	0.9948	More...
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1230:1234	VVSST	SPOP	0.5329	More...
P21583	Kit ligand	DEG_SPOP_SBC_1	164:168	VVSST	SPOP	0.9767	More...
P51003	Poly	DEG_SPOP_SBC_1	615:619	VVSST	SPOP	0.7739	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1337:1341	VVSST	SPOP	0.7602	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1739:1743	VVSST	SPOP	0.9233	More...
Q14241	Elongin-A	DEG_SPOP_SBC_1	763:767	VVSST	SPOP	0.7077	More...
Q8N573	Oxidation resistance protein 1	DEG_SPOP_SBC_1	199:203	VVSST	SPOP	0.9992	More...
Q96B97	SH3 domain-containing kinase-binding protein 1	DEG_SPOP_SBC_1	469:473	VVSST	SPOP	0.9973	More...
Q9BXR0	Queuine tRNA-ribosyltransferase catalytic subunit 1	DEG_SPOP_SBC_1	161:165	VVSST	SPOP	0.5555	More...
Q9HCP0	Casein kinase I isoform gamma-1	DEG_SPOP_SBC_1	370:374	VVSST	SPOP	0.9967	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	337:341	VVSST	SPOP	0.9646	More...
Q9Y6M4	Casein kinase I isoform gamma-3	DEG_SPOP_SBC_1	395:399	VVSST	SPOP	0.9966	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	614:618	VVSST	SPOP	0.8298	More...
Q8NEM2	SHC SH2 domain-binding protein 1	DEG_SPOP_SBC_1	334:338	VVSST	SPOP	0.5138	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVSST

Degron related mutations and impact score

Drug responses associated with ABI2 mutations

All proteins holding degron of VVSST