DegronMD

Uniprot ID: Q9Y6M4

Source protein: Casein kinase I isoform gamma-3

Source gene: CSNK1G3

Class: DEG_SPOP_SBC_1

Location: 395:399

E3 ligase: SPOP

DEGRON score: 0.9966

ASA_SCORE: 71.78

COIL: 0.719

CONS_SCORE: 0.4798

DSS_SCORE: 0.6584

HELIX: 0.0488

FCONS_SCORE: 1.1711

RIG_SCORE: 0.6572

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V396I	TCGA-AX-A05Z	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	0.5965
p.V396I	DO40884	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	0.5965
p.T409N	TCGA-AX-A0J0	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	0.0556
p.T409N	DO41133	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	0.0556
p.N404S	TCGA-DF-A2KN	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	0.1944
p.W406L	DO228985	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.1389
p.W406L	DO37896	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	0.1389
p.G391C	DO50826	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.2222
p.T399I	SIDM00789	Colorectal Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	0.7078
p.T399I	ACH-000997	Colon/Colorectal Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.7078
p.D395Y	ES-2	ovary	COSMIC	VVSST	DEG_SPOP_SBC_1	0.7325
p.D396Y	ES-2	ovary	COSMIC	VVSST	DEG_SPOP_SBC_1	0.7325

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	184:188	VVSST	SPOP	0.9948	More...
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1230:1234	VVSST	SPOP	0.5329	More...
P21583	Kit ligand	DEG_SPOP_SBC_1	164:168	VVSST	SPOP	0.9767	More...
P51003	Poly	DEG_SPOP_SBC_1	615:619	VVSST	SPOP	0.7739	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1337:1341	VVSST	SPOP	0.7602	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1739:1743	VVSST	SPOP	0.9233	More...
Q14241	Elongin-A	DEG_SPOP_SBC_1	763:767	VVSST	SPOP	0.7077	More...
Q8N573	Oxidation resistance protein 1	DEG_SPOP_SBC_1	199:203	VVSST	SPOP	0.9992	More...
Q96B97	SH3 domain-containing kinase-binding protein 1	DEG_SPOP_SBC_1	469:473	VVSST	SPOP	0.9973	More...
Q9BXR0	Queuine tRNA-ribosyltransferase catalytic subunit 1	DEG_SPOP_SBC_1	161:165	VVSST	SPOP	0.5555	More...
Q9HCP0	Casein kinase I isoform gamma-1	DEG_SPOP_SBC_1	370:374	VVSST	SPOP	0.9967	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	337:341	VVSST	SPOP	0.9646	More...
Q9Y6M4	Casein kinase I isoform gamma-3	DEG_SPOP_SBC_1	395:399	VVSST	SPOP	0.9966	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	614:618	VVSST	SPOP	0.8298	More...
Q8NEM2	SHC SH2 domain-binding protein 1	DEG_SPOP_SBC_1	334:338	VVSST	SPOP	0.5138	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons