DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VVSST
Uniprot ID:
Q9BXR0
Source protein:
Queuine tRNA-ribosyltransferase catalytic subunit 1
Source gene:
QTRT1
Class:
DEG_SPOP_SBC_1
Location:
161:165
E3 ligase:
SPOP
DEGRON score:
0.5555
ASA_SCORE:
53.3
COIL:
0.762
CONS_SCORE:
0.5505
DSS_SCORE:
0.2837
HELIX:
0.184
FCONS_SCORE:
0.8607
RIG_SCORE:
0.8098
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R170H
TCGA-51-6867
LUSC
TCGA
VVSST
DEG_SPOP_SBC_1
0.1944
p.R170H
DO26477
LUSC
ICGC
VVSST
DEG_SPOP_SBC_1
0.1944
p.V161M
TCGA-A5-A0G2
UCEC
TCGA
VVSST
DEG_SPOP_SBC_1
0.7208
p.V161M
DO228123
EOPC
ICGC
VVSST
DEG_SPOP_SBC_1
0.7208
p.V161M
DO41235
UCEC
ICGC
VVSST
DEG_SPOP_SBC_1
0.7208
p.P169S
TCGA-A5-A0G2
UCEC
TCGA
VVSST
DEG_SPOP_SBC_1
0.2222
p.P169S
DO41235
UCEC
ICGC
VVSST
DEG_SPOP_SBC_1
0.2222
p.D160N
TCGA-BT-A3PJ
BLCA
TCGA
VVSST
DEG_SPOP_SBC_1
0.3056
p.D160N
DO44097
BLCA
ICGC
VVSST
DEG_SPOP_SBC_1
0.3056
p.R170C
DO223050
ESCA
ICGC
VVSST
DEG_SPOP_SBC_1
0.1944
p.G151C
DO233267
GACA
ICGC
VVSST
DEG_SPOP_SBC_1
0.0556
p.S163I
DO229025
LICA
ICGC
VVSST
DEG_SPOP_SBC_1
0.7341
p.I154N
SIDM00428
Acute Myeloid Leukemia
GDSC
VVSST
DEG_SPOP_SBC_1
0.1389
p.M175I
SIDM00145
T-Lymphoblastic Leukemia
GDSC
VVSST
DEG_SPOP_SBC_1
0.0556
p.M175I
ACH-001127
Leukemia
CCLE
VVSST
DEG_SPOP_SBC_1
0.0556
p.M175I
MOLT-4
haematopoietic_and_lymphoid_tissue
COSMIC
VVSST
DEG_SPOP_SBC_1
0.0556
Drug responses associated with QTRT1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VVSST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O43294
Transforming growth factor beta-1-induced transcript 1 protein
DEG_SPOP_SBC_1
184:188
VVSST
SPOP
0.9948
More...
P16144
Integrin beta-4
DEG_SPOP_SBC_1
1230:1234
VVSST
SPOP
0.5329
More...
P21583
Kit ligand
DEG_SPOP_SBC_1
164:168
VVSST
SPOP
0.9767
More...
P51003
Poly
DEG_SPOP_SBC_1
615:619
VVSST
SPOP
0.7739
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
1337:1341
VVSST
SPOP
0.7602
More...
Q12830
Nucleosome-remodeling factor subunit BPTF
DEG_SPOP_SBC_1
1739:1743
VVSST
SPOP
0.9233
More...
Q14241
Elongin-A
DEG_SPOP_SBC_1
763:767
VVSST
SPOP
0.7077
More...
Q8N573
Oxidation resistance protein 1
DEG_SPOP_SBC_1
199:203
VVSST
SPOP
0.9992
More...
Q96B97
SH3 domain-containing kinase-binding protein 1
DEG_SPOP_SBC_1
469:473
VVSST
SPOP
0.9973
More...
Q9BXR0
Queuine tRNA-ribosyltransferase catalytic subunit 1
DEG_SPOP_SBC_1
161:165
VVSST
SPOP
0.5555
More...
Q9HCP0
Casein kinase I isoform gamma-1
DEG_SPOP_SBC_1
370:374
VVSST
SPOP
0.9967
More...
Q9NYB9
Abl interactor 2
DEG_SPOP_SBC_1
337:341
VVSST
SPOP
0.9646
More...
Q9Y6M4
Casein kinase I isoform gamma-3
DEG_SPOP_SBC_1
395:399
VVSST
SPOP
0.9966
More...
Q9NRJ5
Poly
DEG_SPOP_SBC_1
614:618
VVSST
SPOP
0.8298
More...
Q8NEM2
SHC SH2 domain-binding protein 1
DEG_SPOP_SBC_1
334:338
VVSST
SPOP
0.5138
More...