DegronMD - Q9BXR0(QTRT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R170H	TCGA-51-6867	LUSC	TCGA	VVSST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1944
p.R170H	DO26477	LUSC	ICGC	VVSST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1944
p.V161M	TCGA-A5-A0G2	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7208
p.V161M	DO228123	EOPC	ICGC	VVSST	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7208
p.V161M	DO41235	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7208
p.P169S	TCGA-A5-A0G2	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2222
p.P169S	DO41235	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2222
p.D160N	TCGA-BT-A3PJ	BLCA	TCGA	VVSST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.3056
p.D160N	DO44097	BLCA	ICGC	VVSST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.3056
p.R170C	DO223050	ESCA	ICGC	VVSST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1944
p.G151C	DO233267	GACA	ICGC	VVSST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0556
p.S163I	DO229025	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7341
p.I154N	SIDM00428	Acute Myeloid Leukemia	GDSC	VVSST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1389
p.M175I	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VVSST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0556
p.M175I	ACH-001127	Leukemia	CCLE	VVSST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0556
p.M175I	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0556

Kaplan plot for QTRT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

QTRT1

UniProt ID: Q9BXR0

Entrez ID: 81890

Protein name: Queuine tRNA-ribosyltransferase catalytic subunit 1 (EC 2.4.2.64) (Guanine insertion enzyme) (tRNA-guanine transglycosylase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for QTRT1 in