DegronMD

Uniprot ID: Q9NRJ5

Source protein: Poly

Source gene: PAPOLB

Class: DEG_SPOP_SBC_1

Location: 614:618

E3 ligase: SPOP

DEGRON score: 0.8298

ASA_SCORE: 78.26

COIL: 0.8744

CONS_SCORE: 0.2083

DSS_SCORE: 0.2879

HELIX: 0.0494

FCONS_SCORE: 0.967

RIG_SCORE: 0.7813

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V614F	TCGA-86-8054	LUAD	TCGA	VVSST	DEG_SPOP_SBC_1	0.7068
p.V614F	DO23923	LUAD	ICGC	VVSST	DEG_SPOP_SBC_1	0.7068
p.M609I	TCGA-AX-A2HD	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	0.1944
p.M609I	DO42608	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	0.1944
p.A611T	TCGA-EC-A1NJ	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	0.25
p.A611T	DO40855	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	0.25
p.D624G	TCGA-EO-A3AY	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	0.1667
p.D624G	DO43202	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	0.1667
p.V613A	TCGA-HU-A4G8	STAD	TCGA	VVSST	DEG_SPOP_SBC_1	0.3056
p.V613A	DO47819	STAD	ICGC	VVSST	DEG_SPOP_SBC_1	0.3056
p.V613L	TCGA-VR-A8EY	ESCA	TCGA	VVSST	DEG_SPOP_SBC_1	0.3056
p.P606Q	DO229037	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.1111
p.S621R	DO229045	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.25
p.A608S	DO32916	PACA	ICGC	VVSST	DEG_SPOP_SBC_1	0.2778
p.P604S	DO229502	SKCA	ICGC	VVSST	DEG_SPOP_SBC_1	0.0556
p.H623Y	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	0.1944
p.E628V	SIDM00989	Bladder Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	0.0556
p.E628V	BFTC-905	urinary_tract	COSMIC	VVSST	DEG_SPOP_SBC_1	0.0556
p.E627V	ACH-000802	Bladder Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	184:188	VVSST	SPOP	0.9948	More...
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1230:1234	VVSST	SPOP	0.5329	More...
P21583	Kit ligand	DEG_SPOP_SBC_1	164:168	VVSST	SPOP	0.9767	More...
P51003	Poly	DEG_SPOP_SBC_1	615:619	VVSST	SPOP	0.7739	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1337:1341	VVSST	SPOP	0.7602	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1739:1743	VVSST	SPOP	0.9233	More...
Q14241	Elongin-A	DEG_SPOP_SBC_1	763:767	VVSST	SPOP	0.7077	More...
Q8N573	Oxidation resistance protein 1	DEG_SPOP_SBC_1	199:203	VVSST	SPOP	0.9992	More...
Q96B97	SH3 domain-containing kinase-binding protein 1	DEG_SPOP_SBC_1	469:473	VVSST	SPOP	0.9973	More...
Q9BXR0	Queuine tRNA-ribosyltransferase catalytic subunit 1	DEG_SPOP_SBC_1	161:165	VVSST	SPOP	0.5555	More...
Q9HCP0	Casein kinase I isoform gamma-1	DEG_SPOP_SBC_1	370:374	VVSST	SPOP	0.9967	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	337:341	VVSST	SPOP	0.9646	More...
Q9Y6M4	Casein kinase I isoform gamma-3	DEG_SPOP_SBC_1	395:399	VVSST	SPOP	0.9966	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	614:618	VVSST	SPOP	0.8298	More...
Q8NEM2	SHC SH2 domain-binding protein 1	DEG_SPOP_SBC_1	334:338	VVSST	SPOP	0.5138	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons