DegronMD

Uniprot ID: P51003

Source protein: Poly

Source gene: PAPOLA

Class: DEG_SPOP_SBC_1

Location: 615:619

E3 ligase: SPOP

DEGRON score: 0.7739

ASA_SCORE: 87.92

COIL: 0.8454

CONS_SCORE: 0.1351

DSS_SCORE: 0.6698

HELIX: 0.0244

FCONS_SCORE: -0.0015

RIG_SCORE: 0.7024

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R620C	TCGA-CK-6748	COAD	TCGA	VVSST	DEG_SPOP_SBC_1	0.3056
p.R620C	DO7816	COAD	ICGC	VVSST	DEG_SPOP_SBC_1	0.3056
p.P610S	TCGA-CR-7371	HNSC	TCGA	VVSST	DEG_SPOP_SBC_1	0.1944
p.P610S	DO15454	HNSC	ICGC	VVSST	DEG_SPOP_SBC_1	0.1944
p.S617Y	TCGA-EI-6917	READ	TCGA	VVSST	DEG_SPOP_SBC_1	0.8231
p.S617Y	DO36881	READ	ICGC	VVSST	DEG_SPOP_SBC_1	0.8231
p.S629L	TCGA-EK-A3GK	CESC	TCGA	VVSST	DEG_SPOP_SBC_1	0.0556
p.S629L	DO49964	CESC	ICGC	VVSST	DEG_SPOP_SBC_1	0.0556
p.P606T	TCGA-FD-A43P	BLCA	TCGA	VVSST	DEG_SPOP_SBC_1	0.0833
p.P606T	DO44049	BLCA	ICGC	VVSST	DEG_SPOP_SBC_1	0.0833
p.R620H	DO233888	GACA	ICGC	VVSST	DEG_SPOP_SBC_1	0.3056
p.V622L	DO228976	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.25
p.V616F	DO229026	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.5957
p.R627I	DO229006	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.1111
p.R620L	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	0.3056
p.R620L	ACH-000638	Lung Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.3056
p.R620L	NCI-H441	lung	COSMIC	VVSST	DEG_SPOP_SBC_1	0.3056
p.R627G	SIDM01393	Gastric Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	0.1111
p.R627G	ACH-000466	Gastric Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.1111
p.T611M	ACH-002026	Endometrial/Uterine Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	184:188	VVSST	SPOP	0.9948	More...
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1230:1234	VVSST	SPOP	0.5329	More...
P21583	Kit ligand	DEG_SPOP_SBC_1	164:168	VVSST	SPOP	0.9767	More...
P51003	Poly	DEG_SPOP_SBC_1	615:619	VVSST	SPOP	0.7739	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1337:1341	VVSST	SPOP	0.7602	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1739:1743	VVSST	SPOP	0.9233	More...
Q14241	Elongin-A	DEG_SPOP_SBC_1	763:767	VVSST	SPOP	0.7077	More...
Q8N573	Oxidation resistance protein 1	DEG_SPOP_SBC_1	199:203	VVSST	SPOP	0.9992	More...
Q96B97	SH3 domain-containing kinase-binding protein 1	DEG_SPOP_SBC_1	469:473	VVSST	SPOP	0.9973	More...
Q9BXR0	Queuine tRNA-ribosyltransferase catalytic subunit 1	DEG_SPOP_SBC_1	161:165	VVSST	SPOP	0.5555	More...
Q9HCP0	Casein kinase I isoform gamma-1	DEG_SPOP_SBC_1	370:374	VVSST	SPOP	0.9967	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	337:341	VVSST	SPOP	0.9646	More...
Q9Y6M4	Casein kinase I isoform gamma-3	DEG_SPOP_SBC_1	395:399	VVSST	SPOP	0.9966	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	614:618	VVSST	SPOP	0.8298	More...
Q8NEM2	SHC SH2 domain-binding protein 1	DEG_SPOP_SBC_1	334:338	VVSST	SPOP	0.5138	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons