DegronMD

Uniprot ID: Q8NEM2

Source protein: SHC SH2 domain-binding protein 1

Source gene: SHCBP1

Class: DEG_SPOP_SBC_1

Location: 334:338

E3 ligase: SPOP

DEGRON score: 0.5138

ASA_SCORE: 19.68

COIL: 0.1862

CONS_SCORE: 0.5393

DSS_SCORE: 0.3184

HELIX: 0.133

FCONS_SCORE: 1.2038

RIG_SCORE: 0.7982

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R325H	TCGA-AD-6964	COAD	TCGA	VVSST	DEG_SPOP_SBC_1	0.0833
p.R325H	TCGA-D7-A6EY	STAD	TCGA	VVSST	DEG_SPOP_SBC_1	0.0833
p.R325H	DO8360	COAD	ICGC	VVSST	DEG_SPOP_SBC_1	0.0833
p.R325H	DO50118	STAD	ICGC	VVSST	DEG_SPOP_SBC_1	0.0833
p.R325C	TCGA-D1-A17H	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	0.0833
p.R325C	DO41847	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	0.0833
p.R345Q	TCGA-EA-A410	CESC	TCGA	VVSST	DEG_SPOP_SBC_1	0.1389
p.R345Q	DO49929	CESC	ICGC	VVSST	DEG_SPOP_SBC_1	0.1389
p.R345Q	SIDM01154	T-Lymphoblastic Leukemia	GDSC	VVSST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	184:188	VVSST	SPOP	0.9948	More...
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1230:1234	VVSST	SPOP	0.5329	More...
P21583	Kit ligand	DEG_SPOP_SBC_1	164:168	VVSST	SPOP	0.9767	More...
P51003	Poly	DEG_SPOP_SBC_1	615:619	VVSST	SPOP	0.7739	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1337:1341	VVSST	SPOP	0.7602	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1739:1743	VVSST	SPOP	0.9233	More...
Q14241	Elongin-A	DEG_SPOP_SBC_1	763:767	VVSST	SPOP	0.7077	More...
Q8N573	Oxidation resistance protein 1	DEG_SPOP_SBC_1	199:203	VVSST	SPOP	0.9992	More...
Q96B97	SH3 domain-containing kinase-binding protein 1	DEG_SPOP_SBC_1	469:473	VVSST	SPOP	0.9973	More...
Q9BXR0	Queuine tRNA-ribosyltransferase catalytic subunit 1	DEG_SPOP_SBC_1	161:165	VVSST	SPOP	0.5555	More...
Q9HCP0	Casein kinase I isoform gamma-1	DEG_SPOP_SBC_1	370:374	VVSST	SPOP	0.9967	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	337:341	VVSST	SPOP	0.9646	More...
Q9Y6M4	Casein kinase I isoform gamma-3	DEG_SPOP_SBC_1	395:399	VVSST	SPOP	0.9966	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	614:618	VVSST	SPOP	0.8298	More...
Q8NEM2	SHC SH2 domain-binding protein 1	DEG_SPOP_SBC_1	334:338	VVSST	SPOP	0.5138	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons