DegronMD - Q9NYB9(ABI2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P324H	TCGA-06-5416	GBM	TCGA	VPSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.0556
p.P308H	TCGA-A3-3387	KIRC	TCGA	VPSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.2778
p.P401H	TCGA-BF-A1PU	SKCM	TCGA	NGGPFYSQNP	CBL_PTK	388:397	Mutation rewiring degron network	0.2222
p.Q328H	TCGA-CM-5344	COAD	TCGA	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.0833
p.Q328H	TCGA-DD-AADR	LIHC	TCGA	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.0833
p.Q328H	TCGA-EY-A1G7	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.0833
p.Q346K	TCGA-DK-AA6W	BLCA	TCGA	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1944
p.Q346K	DO219009	BLCA	ICGC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1944
p.V343I	TCGA-EO-A22U	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.2778
p.V343I	DO43755	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.2778
p.S301T	TCGA-HU-8602	STAD	TCGA	VPSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.0833
p.P330A	TCGA-SX-A7SL	KIRP	TCGA	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1389
p.D345H	DO51859	BLCA	ICGC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.2222
p.P315S	DO225337	BRCA	ICGC	VPSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.3056
p.Q340H	DO10252	COAD	ICGC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation altering degron motif	0.7582
p.Q340H	DO52245	LIHC	ICGC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation altering degron motif	0.7582
p.Q340H	DO41223	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation altering degron motif	0.7582
p.T306A	DO227987	COCA	ICGC	VPSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.2222
p.T309I	DO233911	GACA	ICGC	VPSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.3056
p.P336H	DO10880	GBM	ICGC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.3056
p.P342H	DO17323	KIRC	ICGC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.3056
p.D345Y	DO16696	KIRC	ICGC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.2222
p.P342A	DO49783	KIRP	ICGC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.3056
p.A334S	DO229038	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.25
p.I310L	DO231851	LINC	ICGC	VPSST	DEG_SPOP_SBC_1	310:314	Mutation altering degron motif	0.7174
p.V379I	DO45097	LIRI	ICGC	NGGPFYSQNP	CBL_PTK	388:397	Mutation rewiring degron network	0.0833
p.R395C	DO24409	LUAD	ICGC	NGGPFYSQNP	CBL_PTK	388:397	Mutation altering degron motif	0.8301
p.P384H	DO50278	SKCM	ICGC	NGGPFYSQNP	CBL_PTK	388:397	Mutation rewiring degron network	0.2222
p.R395H	DO48016	STAD	ICGC	NGGPFYSQNP	CBL_PTK	388:397	Mutation altering degron motif	0.8244
p.S313T	DO47829	STAD	ICGC	VPSST	DEG_SPOP_SBC_1	310:314	Mutation altering degron motif	0.6005
p.L383H	SIDM00084	Glioblastoma	GDSC	NGGPFYSQNP	CBL_PTK	388:397	Mutation rewiring degron network	0.1944
p.L383H	SIDM00198	Ewing's Sarcoma	GDSC	NGGPFYSQNP	CBL_PTK	388:397	Mutation rewiring degron network	0.1944
p.L383H	SF295	central nervous system	COSMIC	NGGPFYSQNP	CBL_PTK	388:397	Mutation rewiring degron network	0.1944
p.L341I	SIDM01259	B-Lymphoblastic Leukemia	GDSC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation altering degron motif	0.7174
p.L341I	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation altering degron motif	0.7174
p.P335T	SIDM00917	Acute Myeloid Leukemia	GDSC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.2778
p.P335T	CESS	haematopoietic and lymphoid tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.2778
p.P347L	SIDM00429	B-Lymphoblastic Leukemia	GDSC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1667
p.P347L	NALM-6	haematopoietic and lymphoid tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1667
p.D328Y	SIDM00920	Breast Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.0833
p.D328Y	CAMA-1	breast	COSMIC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.0833
p.P302H	SIDM00783	Colorectal Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1111
p.P302H	ACH-000971	Colon/Colorectal Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1111
p.P302H	HCT-116	large intestine	COSMIC	VPSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1111
p.T331A	ACH-000881	Skin Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1667
p.T331A	MEL-JUSO	skin	COSMIC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1667
p.P314L	ACH-000938	Leukemia	CCLE	VPSST	DEG_SPOP_SBC_1	310:314	Mutation altering degron motif	0.7582
p.P314L	NALM-6	haematopoietic and lymphoid tissue	COSMIC	VPSST	DEG_SPOP_SBC_1	310:314	Mutation altering degron motif	0.7582
p.A315V	ACH-000982	Colon/Colorectal Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.3056
p.P406H	ACH-001063	Ovarian Cancer	CCLE	NGGPFYSQNP	CBL_PTK	388:397	Mutation rewiring degron network	0.0833
p.L328H	SF295	central nervous system	COSMIC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.0833
p.P341L	NALM-6	haematopoietic and lymphoid tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation altering degron motif	0.7582
p.L350H	SF295	central nervous system	COSMIC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.0833
p.V402A	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	NGGPFYSQNP	CBL_PTK	388:397	Mutation rewiring degron network	0.1944
p.A393T	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	NGGPFYSQNP	CBL_PTK	388:397	Mutation altering degron motif	0.7139
p.P302T	CESS	haematopoietic and lymphoid tissue	COSMIC	VPSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1111
p.D322Y	CAMA-1	breast	COSMIC	VPSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1111
p.L316H	SF295	central nervous system	COSMIC	VPSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.2778
p.P323L	HPAC	pancreas	COSMIC	VPSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.0833
p.V334A	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.25
p.T309A	MEL-JUSO	skin	COSMIC	VPSST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.3056
p.P391L	HPAC	pancreas	COSMIC	NGGPFYSQNP	CBL_PTK	388:397	Mutation altering degron motif	0.6471
p.P329T	CESS	haematopoietic and lymphoid tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1111

Kaplan plot for ABI2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABI2

UniProt ID: Q9NYB9

Entrez ID: 10152

Protein name: Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABI2 in