DegronMD

Uniprot ID: Q9NYB9

Source protein: Abl interactor 2

Source gene: ABI2

Class: CBL_PTK

Location: 388:397

E3 ligase: CBL

DEGRON score: 0.9425

ASA_SCORE: 72.93

COIL: 0.9022

CONS_SCORE: 0.297

DSS_SCORE: 0.7883

HELIX: 0.0502

FCONS_SCORE: 0.7958

RIG_SCORE: 0.5702

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P401H	TCGA-BF-A1PU	SKCM	TCGA	NGGPFYSQNP	CBL_PTK	0.2222
p.V379I	DO45097	LIRI	ICGC	NGGPFYSQNP	CBL_PTK	0.0833
p.R395C	DO24409	LUAD	ICGC	NGGPFYSQNP	CBL_PTK	0.8301
p.P384H	DO50278	SKCM	ICGC	NGGPFYSQNP	CBL_PTK	0.2222
p.R395H	DO48016	STAD	ICGC	NGGPFYSQNP	CBL_PTK	0.8244
p.L383H	SIDM00084	Glioblastoma	GDSC	NGGPFYSQNP	CBL_PTK	0.1944
p.L383H	SIDM00198	Ewing's Sarcoma	GDSC	NGGPFYSQNP	CBL_PTK	0.1944
p.L383H	SF295	central_nervous_system	COSMIC	NGGPFYSQNP	CBL_PTK	0.1944
p.P406H	ACH-001063	Ovarian Cancer	CCLE	NGGPFYSQNP	CBL_PTK	0.0833
p.V402A	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	NGGPFYSQNP	CBL_PTK	0.1944
p.A393T	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	NGGPFYSQNP	CBL_PTK	0.7139
p.P391L	HPAC	pancreas	COSMIC	NGGPFYSQNP	CBL_PTK	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYB9	Abl interactor 2	CBL_PTK	388:397	NGGPFYSQNP	CBL	0.9425	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons