DegronMD

Uniprot ID: Q9NYB9

Source protein: Abl interactor 2

Source gene: ABI2

Class: DEG_SPOP_SBC_1

Location: 310:314

E3 ligase: SPOP

DEGRON score: 0.9925

ASA_SCORE: 79.04

COIL: 0.9484

CONS_SCORE: 0.2978

DSS_SCORE: 0.5032

HELIX: 0.026

FCONS_SCORE: 1.0691

RIG_SCORE: 0.6442

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P324H	TCGA-06-5416	GBM	TCGA	VPSST	DEG_SPOP_SBC_1	0.0556
p.P308H	TCGA-A3-3387	KIRC	TCGA	VPSST	DEG_SPOP_SBC_1	0.2778
p.S301T	TCGA-HU-8602	STAD	TCGA	VPSST	DEG_SPOP_SBC_1	0.0833
p.P315S	DO225337	BRCA	ICGC	VPSST	DEG_SPOP_SBC_1	0.3056
p.T306A	DO227987	COCA	ICGC	VPSST	DEG_SPOP_SBC_1	0.2222
p.T309I	DO233911	GACA	ICGC	VPSST	DEG_SPOP_SBC_1	0.3056
p.I310L	DO231851	LINC	ICGC	VPSST	DEG_SPOP_SBC_1	0.7174
p.S313T	DO47829	STAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.6005
p.P302H	SIDM00783	Colorectal Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1111
p.P302H	ACH-000971	Colon/Colorectal Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	0.1111
p.P302H	HCT-116	large_intestine	COSMIC	VPSST	DEG_SPOP_SBC_1	0.1111
p.P314L	ACH-000938	Leukemia	CCLE	VPSST	DEG_SPOP_SBC_1	0.7582
p.P314L	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	VPSST	DEG_SPOP_SBC_1	0.7582
p.A315V	ACH-000982	Colon/Colorectal Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	0.3056
p.P302T	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	VPSST	DEG_SPOP_SBC_1	0.1111
p.D322Y	CAMA-1	breast	COSMIC	VPSST	DEG_SPOP_SBC_1	0.1111
p.L316H	SF295	central_nervous_system	COSMIC	VPSST	DEG_SPOP_SBC_1	0.2778
p.P323L	HPAC	pancreas	COSMIC	VPSST	DEG_SPOP_SBC_1	0.0833
p.T309A	MEL-JUSO	skin	COSMIC	VPSST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43451	Maltase-glucoamylase	DEG_SPOP_SBC_1	1969:1973	VPSST	SPOP	0.5297	More...
O75509	Tumor necrosis factor receptor superfamily member 21	DEG_SPOP_SBC_1	241:245	VPSST	SPOP	0.9727	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	45:49	VPSST	SPOP	0.9082	More...
P19438	Tumor necrosis factor receptor superfamily member 1A	DEG_SPOP_SBC_1	288:292	VPSST	SPOP	0.9514	More...
Q9H1K0	Rabenosyn-5	DEG_SPOP_SBC_1	580:584	VPSST	SPOP	0.9962	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	156:160	VPSST	SPOP	0.8129	More...
Q9H4W6	Transcription factor COE3	DEG_SPOP_SBC_1	473:477	VPSST	SPOP	0.9884	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	553:557	VPSST	SPOP	0.9515	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	310:314	VPSST	SPOP	0.9925	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	1773:1777	VPSST	SPOP	0.9973	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	643:647	VPSST	SPOP	0.9721	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	536:540	VPSST	SPOP	0.998	More...
Q6ZNC4	Zinc finger protein 704	DEG_SPOP_SBC_1	121:125	VPSST	SPOP	0.9625	More...
Q96LR7	Uncharacterized protein C2orf50	DEG_SPOP_SBC_1	119:123	VPSST	SPOP	0.8932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons