DegronMD

Uniprot ID: Q96LR7

Source protein: Uncharacterized protein C2orf50

Source gene: C2orf50

Class: DEG_SPOP_SBC_1

Location: 119:123

E3 ligase: SPOP

DEGRON score: 0.8932

ASA_SCORE: 46.84

COIL: 0.7952

CONS_SCORE: 0.8463

DSS_SCORE: 0.457

HELIX: 0.0696

FCONS_SCORE: 1.0204

RIG_SCORE: 0.6786

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P109S	TCGA-A6-5661	COAD	TCGA	VPSST	DEG_SPOP_SBC_1	0.0556
p.P109S	DO8634	COAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.0556
p.S129N	TCGA-AN-A0AK	BRCA	TCGA	VPSST	DEG_SPOP_SBC_1	0.1667
p.S129N	DO1608	BRCA	ICGC	VPSST	DEG_SPOP_SBC_1	0.1667
p.D132G	TCGA-B5-A3FA	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	0.0833
p.D132G	DO52402	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	0.0833
p.P120L	TCGA-FW-A3R5	SKCM	TCGA	VPSST	DEG_SPOP_SBC_1	0.6471
p.P120L	DO37406	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43451	Maltase-glucoamylase	DEG_SPOP_SBC_1	1969:1973	VPSST	SPOP	0.5297	More...
O75509	Tumor necrosis factor receptor superfamily member 21	DEG_SPOP_SBC_1	241:245	VPSST	SPOP	0.9727	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	45:49	VPSST	SPOP	0.9082	More...
P19438	Tumor necrosis factor receptor superfamily member 1A	DEG_SPOP_SBC_1	288:292	VPSST	SPOP	0.9514	More...
Q9H1K0	Rabenosyn-5	DEG_SPOP_SBC_1	580:584	VPSST	SPOP	0.9962	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	156:160	VPSST	SPOP	0.8129	More...
Q9H4W6	Transcription factor COE3	DEG_SPOP_SBC_1	473:477	VPSST	SPOP	0.9884	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	553:557	VPSST	SPOP	0.9515	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	310:314	VPSST	SPOP	0.9925	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	1773:1777	VPSST	SPOP	0.9973	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	643:647	VPSST	SPOP	0.9721	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	536:540	VPSST	SPOP	0.998	More...
Q6ZNC4	Zinc finger protein 704	DEG_SPOP_SBC_1	121:125	VPSST	SPOP	0.9625	More...
Q96LR7	Uncharacterized protein C2orf50	DEG_SPOP_SBC_1	119:123	VPSST	SPOP	0.8932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons