DegronMD

Uniprot ID: Q9H4A3

Source protein: Serine/threonine-protein kinase WNK1

Source gene: WNK1

Class: DEG_SPOP_SBC_1

Location: 156:160

E3 ligase: SPOP

DEGRON score: 0.8129

ASA_SCORE: 86.84

COIL: 0.9262

CONS_SCORE: 0.3062

DSS_SCORE: 0.7396

HELIX: 0.0328

FCONS_SCORE: 0.9484

RIG_SCORE: 0.5474

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T160N	TCGA-78-8640	LUAD	TCGA	VPSST	DEG_SPOP_SBC_1	0.7055
p.T160N	DO45340	LUAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.7055
p.I151M	DO474	BLCA	ICGC	VPSST	DEG_SPOP_SBC_1	0.1944
p.A152T	DO222874	COCA	ICGC	VPSST	DEG_SPOP_SBC_1	0.2222
p.A148S	DO27302	LUSC	ICGC	VPSST	DEG_SPOP_SBC_1	0.1111
p.S154W	DO228498	PRAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.2778
p.R159W	DO38404	STAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.8634
p.A152V	DO219773	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	0.2222
p.Y150C	DO42825	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	0.1667
p.A149V	SIDM00611	Kidney Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1389
p.A149V	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1389
p.A149V	SIDM00157	Neuroblastoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1389
p.A149V	SIDM00362	Burkitt's Lymphoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1389
p.A149V	SIDM00240	Cervical Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1389
p.A149V	SIDM00192	Colorectal Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1389
p.A149V	SIDM01682	Gastric Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1389
p.A149V	SIDM01377	Ovarian Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1389
p.A149V	SIDM01469	Pancreatic Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1389
p.A149V	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1389
p.A149V	SIDM01316	Ewing's Sarcoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1389
p.A149V	SIDM00164	Biliary Tract Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1389
p.A149V	SIDM00500	Colorectal Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1389
p.A149V	SIDM01391	Neuroblastoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1389
p.P153L	ACH-001419	Breast Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	0.25
p.G153E	REH	haematopoietic_and_lymphoid_tissue	COSMIC	VPSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43451	Maltase-glucoamylase	DEG_SPOP_SBC_1	1969:1973	VPSST	SPOP	0.5297	More...
O75509	Tumor necrosis factor receptor superfamily member 21	DEG_SPOP_SBC_1	241:245	VPSST	SPOP	0.9727	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	45:49	VPSST	SPOP	0.9082	More...
P19438	Tumor necrosis factor receptor superfamily member 1A	DEG_SPOP_SBC_1	288:292	VPSST	SPOP	0.9514	More...
Q9H1K0	Rabenosyn-5	DEG_SPOP_SBC_1	580:584	VPSST	SPOP	0.9962	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	156:160	VPSST	SPOP	0.8129	More...
Q9H4W6	Transcription factor COE3	DEG_SPOP_SBC_1	473:477	VPSST	SPOP	0.9884	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	553:557	VPSST	SPOP	0.9515	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	310:314	VPSST	SPOP	0.9925	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	1773:1777	VPSST	SPOP	0.9973	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	643:647	VPSST	SPOP	0.9721	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	536:540	VPSST	SPOP	0.998	More...
Q6ZNC4	Zinc finger protein 704	DEG_SPOP_SBC_1	121:125	VPSST	SPOP	0.9625	More...
Q96LR7	Uncharacterized protein C2orf50	DEG_SPOP_SBC_1	119:123	VPSST	SPOP	0.8932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPSST

Degron related mutations and impact score

Drug responses associated with WNK1 mutations

All proteins holding degron of VPSST