DegronMD

Uniprot ID: P15941

Source protein: Mucin-1

Source gene: MUC1

Class: DEG_SPOP_SBC_1

Location: 45:49

E3 ligase: SPOP

DEGRON score: 0.9082

ASA_SCORE: 89.1

COIL: 0.9572

CONS_SCORE: 0.4357

DSS_SCORE: 0.6507

HELIX: 0.0206

FCONS_SCORE: 0.9803

RIG_SCORE: 0.6145

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S47R	TCGA-3U-A98E	MESO	TCGA	VPSST	DEG_SPOP_SBC_1	0.7427
p.S47R	DO229029	LICA	ICGC	VPSST	DEG_SPOP_SBC_1	0.7427
p.S55N	TCGA-AP-A059	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	0.1667
p.S55N	BICR10	upper_aerodigestive_tract	COSMIC	VPSST	DEG_SPOP_SBC_1	0.1667
p.R42I	TCGA-BK-A6W3	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	0.25
p.R42I	DO50076	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	0.25
p.E50K	TCGA-VS-A958	CESC	TCGA	VPSST	DEG_SPOP_SBC_1	0.3056
p.E50K	DO51639	CESC	ICGC	VPSST	DEG_SPOP_SBC_1	0.3056
p.P57Q	DO229041	LICA	ICGC	VPSST	DEG_SPOP_SBC_1	0.1111
p.G59S	DO222749	MELA	ICGC	VPSST	DEG_SPOP_SBC_1	0.0556
p.G57V	DO47374	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	0.1111
p.G59D	DO38723	STAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.0556
p.T56I	DO230449	UTCA	ICGC	VPSST	DEG_SPOP_SBC_1	0.1389
p.G41C	SIDM00789	Colorectal Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.2222
p.G41C	HCT-15	large_intestine	COSMIC	VPSST	DEG_SPOP_SBC_1	0.2222
p.S37I	SIDM00479	Esophageal Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.1111
p.S37I	OE19	oesophagus	COSMIC	VPSST	DEG_SPOP_SBC_1	0.1111
p.S58N	ACH-001331	Head and Neck Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	0.0833
p.S58N	BICR10	upper_aerodigestive_tract	COSMIC	VPSST	DEG_SPOP_SBC_1	0.0833
p.S58R	ACH-002222	Leukemia	CCLE	VPSST	DEG_SPOP_SBC_1	0.0833
p.S58R	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	VPSST	DEG_SPOP_SBC_1	0.0833
p.A53D	ACH-002256	Leukemia	CCLE	VPSST	DEG_SPOP_SBC_1	0.2222
p.A53D	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VPSST	DEG_SPOP_SBC_1	0.2222
p.S57F	SW684	soft_tissue	COSMIC	VPSST	DEG_SPOP_SBC_1	0.1111
p.V57I	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VPSST	DEG_SPOP_SBC_1	0.1111
p.S55R	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	VPSST	DEG_SPOP_SBC_1	0.1667
p.A50D	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VPSST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43451	Maltase-glucoamylase	DEG_SPOP_SBC_1	1969:1973	VPSST	SPOP	0.5297	More...
O75509	Tumor necrosis factor receptor superfamily member 21	DEG_SPOP_SBC_1	241:245	VPSST	SPOP	0.9727	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	45:49	VPSST	SPOP	0.9082	More...
P19438	Tumor necrosis factor receptor superfamily member 1A	DEG_SPOP_SBC_1	288:292	VPSST	SPOP	0.9514	More...
Q9H1K0	Rabenosyn-5	DEG_SPOP_SBC_1	580:584	VPSST	SPOP	0.9962	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	156:160	VPSST	SPOP	0.8129	More...
Q9H4W6	Transcription factor COE3	DEG_SPOP_SBC_1	473:477	VPSST	SPOP	0.9884	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	553:557	VPSST	SPOP	0.9515	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	310:314	VPSST	SPOP	0.9925	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	1773:1777	VPSST	SPOP	0.9973	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	643:647	VPSST	SPOP	0.9721	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	536:540	VPSST	SPOP	0.998	More...
Q6ZNC4	Zinc finger protein 704	DEG_SPOP_SBC_1	121:125	VPSST	SPOP	0.9625	More...
Q96LR7	Uncharacterized protein C2orf50	DEG_SPOP_SBC_1	119:123	VPSST	SPOP	0.8932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPSST

Degron related mutations and impact score

Drug responses associated with MUC1 mutations

All proteins holding degron of VPSST