DegronMD - O43451(MGAM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1160T	TCGA-44-2659	LUAD	TCGA	PPGY	ITCH	1159:1162	Mutation altering degron motif	0.7031
p.P1160T	DO23744	LUAD	ICGC	PPGY	ITCH	1159:1162	Mutation altering degron motif	0.7031
p.P1159L	TCGA-D3-A8GM	SKCM	TCGA	PPGY	ITCH	1159:1162	Mutation altering degron motif	0.7582
p.P1159L	DO50288	SKCM	ICGC	PPGY	ITCH	1159:1162	Mutation altering degron motif	0.7582
p.K1164M	TCGA-E6-A1LX	UCEC	TCGA	PPGY	ITCH	1159:1162	Mutation rewiring degron network	0.2778
p.K1164M	DO232070	ORCA	ICGC	PPGY	ITCH	1159:1162	Mutation rewiring degron network	0.2778
p.K1164M	DO41020	UCEC	ICGC	PPGY	ITCH	1159:1162	Mutation rewiring degron network	0.2778
p.S1166F	TCGA-EB-A431	SKCM	TCGA	PPGY	ITCH	1159:1162	Mutation rewiring degron network	0.2222
p.S1166F	TCGA-FS-A4F5	SKCM	TCGA	PPGY	ITCH	1159:1162	Mutation rewiring degron network	0.2222
p.S1166F	DO37671	SKCM	ICGC	PPGY	ITCH	1159:1162	Mutation rewiring degron network	0.2222
p.S1166F	DO37881	SKCM	ICGC	PPGY	ITCH	1159:1162	Mutation rewiring degron network	0.2222
p.G1161E	TCGA-W3-AA1W	SKCM	TCGA	PPGY	ITCH	1159:1162	Mutation altering degron motif	0.6087
p.G1161E	DO220911	MELA	ICGC	PPGY	ITCH	1159:1162	Mutation altering degron motif	0.6087
p.G1161E	DO51277	SKCM	ICGC	PPGY	ITCH	1159:1162	Mutation altering degron motif	0.6087
p.E1959D	DO52597	BOCA	ICGC	VPSST	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.0556
p.S1971F	DO5249	BRCA	ICGC	VPSST	DEG_SPOP_SBC_1	1969:1973	Mutation altering degron motif	0.7982
p.V1962I	DO230334	COCA	ICGC	VPSST	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1389
p.V1962I	DO229013	COCA	ICGC	VPSST	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1389
p.V1962I	DO229016	COCA	ICGC	VPSST	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1389
p.V1962I	DO52365	LUSC	ICGC	VPSST	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1389
p.L1978R	DO234233	ESAD	ICGC	VPSST	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1944
p.D1157N	DO233797	GACA	ICGC	PPGY	ITCH	1159:1162	Mutation rewiring degron network	0.2778
p.D1157N	DO232008	LICA	ICGC	PPGY	ITCH	1159:1162	Mutation rewiring degron network	0.2778
p.V1969M	DO233941	GACA	ICGC	VPSST	DEG_SPOP_SBC_1	1969:1973	Mutation altering degron motif	0.7208
p.G2057E	DO11854	GBM	ICGC	PPGY	ITCH	2055:2058	Mutation altering degron motif	0.6087
p.G1161W	DO231645	LINC	ICGC	PPGY	ITCH	1159:1162	Mutation altering degron motif	0.6714
p.S2062F	DO26971	LUSC	ICGC	PPGY	ITCH	2055:2058	Mutation rewiring degron network	0.2222
p.S2062F	DO222434	MELA	ICGC	PPGY	ITCH	2055:2058	Mutation rewiring degron network	0.2222
p.S2062F	DO218914	SKCA	ICGC	PPGY	ITCH	2055:2058	Mutation rewiring degron network	0.2222
p.D1980N	DO222363	MELA	ICGC	VPSST	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1389
p.G1976S	DO222546	MELA	ICGC	VPSST	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.25
p.R2052Q	DO222837	MELA	ICGC	PPGY	ITCH	2055:2058	Mutation rewiring degron network	0.25
p.R2052Q	TMK-1	stomach	COSMIC	PPGY	ITCH	2055:2058	Mutation rewiring degron network	0.25
p.P1967T	DO46611	OV	ICGC	VPSST	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.2778
p.F2050L	DO51468	PACA	ICGC	PPGY	ITCH	2055:2058	Mutation rewiring degron network	0.1944
p.G2064S	DO218874	SKCA	ICGC	PPGY	ITCH	2055:2058	Mutation rewiring degron network	0.1667
p.R1156Q	ACH-001194	Kidney Cancer	CCLE	PPGY	ITCH	1159:1162	Mutation rewiring degron network	0.25
p.S1972N	ACH-001522	Skin Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	1969:1973	Mutation altering degron motif	0.7069
p.I1983V	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	VPSST	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.0556
p.G2064R	NCI-H2347	lung	COSMIC	PPGY	ITCH	2055:2058	Mutation rewiring degron network	0.1667

Kaplan plot for MGAM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MGAM

UniProt ID: O43451

Entrez ID: 8972

Protein name: Maltase-glucoamylase (Alpha-1,4-glucosidase) (EC 3.2.1.20)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MGAM in