DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VPSST
Uniprot ID:
Q9H1K0
Source protein:
Rabenosyn-5
Source gene:
RBSN
Class:
DEG_SPOP_SBC_1
Location:
580:584
E3 ligase:
SPOP
DEGRON score:
0.9962
ASA_SCORE:
77.42
COIL:
0.916
CONS_SCORE:
0.3828
DSS_SCORE:
0.6069
HELIX:
0.042
FCONS_SCORE:
0.9779
RIG_SCORE:
0.5834
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S582N
SIDM00120
Prostate Carcinoma
GDSC
VPSST
DEG_SPOP_SBC_1
0.7069
p.S582N
DU-145
prostate
COSMIC
VPSST
DEG_SPOP_SBC_1
0.7069
p.P581S
SIDM01162
Kidney Carcinoma
GDSC
VPSST
DEG_SPOP_SBC_1
0.5641
p.P581S
SW156
kidney
COSMIC
VPSST
DEG_SPOP_SBC_1
0.5641
p.A570S
SIDM00224
Mesothelioma
GDSC
VPSST
DEG_SPOP_SBC_1
0.0556
p.A570S
IST-MES1
pleura
COSMIC
VPSST
DEG_SPOP_SBC_1
0.0556
Drug responses associated with RBSN mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VPSST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O43451
Maltase-glucoamylase
DEG_SPOP_SBC_1
1969:1973
VPSST
SPOP
0.5297
More...
O75509
Tumor necrosis factor receptor superfamily member 21
DEG_SPOP_SBC_1
241:245
VPSST
SPOP
0.9727
More...
P15941
Mucin-1
DEG_SPOP_SBC_1
45:49
VPSST
SPOP
0.9082
More...
P19438
Tumor necrosis factor receptor superfamily member 1A
DEG_SPOP_SBC_1
288:292
VPSST
SPOP
0.9514
More...
Q9H1K0
Rabenosyn-5
DEG_SPOP_SBC_1
580:584
VPSST
SPOP
0.9962
More...
Q9H4A3
Serine/threonine-protein kinase WNK1
DEG_SPOP_SBC_1
156:160
VPSST
SPOP
0.8129
More...
Q9H4W6
Transcription factor COE3
DEG_SPOP_SBC_1
473:477
VPSST
SPOP
0.9884
More...
Q9H9J4
Ubiquitin carboxyl-terminal hydrolase 42
DEG_SPOP_SBC_1
553:557
VPSST
SPOP
0.9515
More...
Q9NYB9
Abl interactor 2
DEG_SPOP_SBC_1
310:314
VPSST
SPOP
0.9925
More...
O14513
Nck-associated protein 5
DEG_SPOP_SBC_1
1773:1777
VPSST
SPOP
0.9973
More...
Q5T8P6
RNA-binding protein 26
DEG_SPOP_SBC_1
643:647
VPSST
SPOP
0.9721
More...
Q9NRJ5
Poly
DEG_SPOP_SBC_1
536:540
VPSST
SPOP
0.998
More...
Q6ZNC4
Zinc finger protein 704
DEG_SPOP_SBC_1
121:125
VPSST
SPOP
0.9625
More...
Q96LR7
Uncharacterized protein C2orf50
DEG_SPOP_SBC_1
119:123
VPSST
SPOP
0.8932
More...