DegronMD

Uniprot ID: P19438

Source protein: Tumor necrosis factor receptor superfamily member 1A

Source gene: TNFRSF1A

Class: DEG_SPOP_SBC_1

Location: 288:292

E3 ligase: SPOP

DEGRON score: 0.9514

ASA_SCORE: 77.18

COIL: 0.9076

CONS_SCORE: 0.5582

DSS_SCORE: 0.4818

HELIX: 0.0358

FCONS_SCORE: 0.9458

RIG_SCORE: 0.632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V288M	TCGA-EO-A22S	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	0.7208
p.V288M	SIDM01245	T-Lymphoblastic Leukemia	GDSC	VPSST	DEG_SPOP_SBC_1	0.7208
p.V288M	SIDM00991	T-Lymphoblastic Leukemia	GDSC	VPSST	DEG_SPOP_SBC_1	0.7208
p.V288M	ACH-000519	Leukemia	CCLE	VPSST	DEG_SPOP_SBC_1	0.7208
p.V288M	ACH-002216	Leukemia	CCLE	VPSST	DEG_SPOP_SBC_1	0.7208
p.V288M	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	VPSST	DEG_SPOP_SBC_1	0.7208
p.P289A	TCGA-OR-A5LP	ACC	TCGA	VPSST	DEG_SPOP_SBC_1	0.6392
p.A283V	DO223732	CESC	ICGC	VPSST	DEG_SPOP_SBC_1	0.1944
p.A283V	DO227976	COCA	ICGC	VPSST	DEG_SPOP_SBC_1	0.1944
p.L286F	DO45089	LINC	ICGC	VPSST	DEG_SPOP_SBC_1	0.2778
p.W298G	DO45197	LIRI	ICGC	VPSST	DEG_SPOP_SBC_1	0.1667
p.L295I	DO37986	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	0.25
p.P294L	DO51294	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	0.2778
p.P294A	DO229208	THCA	ICGC	VPSST	DEG_SPOP_SBC_1	0.2778
p.A285T	DO40879	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	0.25
p.G302S	ACH-001737	Leukemia	CCLE	VPSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43451	Maltase-glucoamylase	DEG_SPOP_SBC_1	1969:1973	VPSST	SPOP	0.5297	More...
O75509	Tumor necrosis factor receptor superfamily member 21	DEG_SPOP_SBC_1	241:245	VPSST	SPOP	0.9727	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	45:49	VPSST	SPOP	0.9082	More...
P19438	Tumor necrosis factor receptor superfamily member 1A	DEG_SPOP_SBC_1	288:292	VPSST	SPOP	0.9514	More...
Q9H1K0	Rabenosyn-5	DEG_SPOP_SBC_1	580:584	VPSST	SPOP	0.9962	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	156:160	VPSST	SPOP	0.8129	More...
Q9H4W6	Transcription factor COE3	DEG_SPOP_SBC_1	473:477	VPSST	SPOP	0.9884	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	553:557	VPSST	SPOP	0.9515	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	310:314	VPSST	SPOP	0.9925	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	1773:1777	VPSST	SPOP	0.9973	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	643:647	VPSST	SPOP	0.9721	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	536:540	VPSST	SPOP	0.998	More...
Q6ZNC4	Zinc finger protein 704	DEG_SPOP_SBC_1	121:125	VPSST	SPOP	0.9625	More...
Q96LR7	Uncharacterized protein C2orf50	DEG_SPOP_SBC_1	119:123	VPSST	SPOP	0.8932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons