DegronMD - Q9NRJ5(PAPOLB)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q503H	TCGA-06-5416	GBM	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.1944
p.Q503H	DO10880	GBM	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.1944
p.G480C	TCGA-18-3407	LUSC	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.0556
p.G480C	DO26454	LUSC	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.0556
p.G480C	DO229218	THCA	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.0556
p.G480D	TCGA-43-7656	LUSC	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.0556
p.G480D	DO26424	LUSC	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.0556
p.I483T	TCGA-4E-A92E	UCEC	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation substituting flanking lysine	0.25
p.I483T	DO223277	UCEC	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation substituting flanking lysine	0.25
p.S549I	TCGA-55-7907	LUAD	TCGA	VPSST	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0833
p.S549I	DO25396	LUAD	ICGC	VPSST	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0833
p.V614F	TCGA-86-8054	LUAD	TCGA	VVSST	DEG_SPOP_SBC_1	614:618	Mutation altering degron motif	0.7068
p.V614F	DO23923	LUAD	ICGC	VVSST	DEG_SPOP_SBC_1	614:618	Mutation altering degron motif	0.7068
p.S538Y	TCGA-A5-A2K5	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	536:540	Mutation altering degron motif	0.712
p.S538Y	DO41379	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	536:540	Mutation altering degron motif	0.712
p.S540I	TCGA-AJ-A3EK	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	536:540	Mutation altering degron motif	0.7341
p.S540I	DO41584	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	536:540	Mutation altering degron motif	0.7341
p.S532I	TCGA-AP-A1DV	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.2222
p.S532I	DO43186	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.2222
p.P428S	TCGA-AP-A1DV	UCEC	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation rewiring degron network	0.1667
p.P428S	DO43186	UCEC	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation rewiring degron network	0.1667
p.M609I	TCGA-AX-A2HD	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.1944
p.M609I	DO42608	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.1944
p.A485V	TCGA-AX-A2HD	UCEC	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation blocking phosphorylation signal	0.6389
p.A485V	DO42608	UCEC	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation blocking phosphorylation signal	0.6389
p.E426G	TCGA-B5-A11E	UCEC	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.E426G	DO41644	UCEC	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.V501A	TCGA-CA-6717	COAD	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.25
p.V501A	DO8264	COAD	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.25
p.S549N	TCGA-D1-A0ZO	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0833
p.S549N	DO41927	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0833
p.M486I	TCGA-D1-A1NY	UCEC	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.2222
p.M486I	DO42512	UCEC	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.2222
p.H500Y	TCGA-D3-A8GI	SKCM	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.2778
p.H500Y	TCGA-EE-A3J4	SKCM	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.2778
p.H500Y	DO50284	SKCM	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.2778
p.H500Y	DO48604	SKCM	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.2778
p.S534Y	TCGA-E6-A1LX	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.2778
p.S534Y	DO41020	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.2778
p.A611T	TCGA-EC-A1NJ	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.25
p.A611T	DO40855	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.25
p.K482T	TCGA-EO-A22U	UCEC	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.1111
p.K482T	DO43755	UCEC	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.1111
p.L452F	TCGA-EO-A3AV	UCEC	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation rewiring degron network	0.0556
p.L452F	DO52412	UCEC	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation rewiring degron network	0.0556
p.D624G	TCGA-EO-A3AY	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.1667
p.D624G	DO43202	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.1667
p.M436I	TCGA-FV-A496	LIHC	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation altering degron motif	0.7618
p.M436I	DO44966	LIHC	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation altering degron motif	0.7618
p.E530Q	TCGA-GV-A3JZ	BLCA	TCGA	VPSST	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1667
p.E530Q	DO773	BLCA	ICGC	VPSST	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1667
p.V613A	TCGA-HU-A4G8	STAD	TCGA	VVSST	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.3056
p.V613A	DO47819	STAD	ICGC	VVSST	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.3056
p.A527T	TCGA-HU-A4GQ	STAD	TCGA	VPSST	DEG_SPOP_SBC_1	536:540	Mutation blocking phosphorylation signal	0.5278
p.A527T	DO47767	STAD	ICGC	VPSST	DEG_SPOP_SBC_1	536:540	Mutation blocking phosphorylation signal	0.5278
p.P498H	TCGA-S5-A6DX	BLCA	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.7694
p.P498H	DO51903	BLCA	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.7694
p.A507S	TCGA-VQ-A91Q	STAD	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation substituting flanking lysine	0.1944
p.A507S	DO51786	STAD	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation substituting flanking lysine	0.1944
p.V613L	TCGA-VR-A8EY	ESCA	TCGA	VVSST	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.3056
p.W437R	TCGA-VS-A9UO	CESC	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation altering degron motif	0.8634
p.W437R	DO219736	CESC	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation altering degron motif	0.8634
p.I483F	DO50570	BOCA	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation substituting flanking lysine	0.25
p.K505R	DO234227	ESAD	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.1389
p.S534F	DO233888	GACA	ICGC	VPSST	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.2778
p.P546T	DO229027	LICA	ICGC	VPSST	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1667
p.P606Q	DO229037	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.1111
p.S621R	DO229045	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.25
p.A608S	DO32916	PACA	ICGC	VVSST	DEG_SPOP_SBC_1	614:618	Mutation substituting flanking lysine	0.2778
p.P604S	DO229502	SKCA	ICGC	VVSST	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.0556
p.M431V	SIDM01137	Pancreatic Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation rewiring degron network	0.25
p.M431V	PANC-04-03	pancreas	COSMIC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation rewiring degron network	0.25
p.K426R	SIDM00933	Breast Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM00773	Non-Cancerous	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM00855	Other Sarcomas	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM00654	Small Cell Lung Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM00529	Breast Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM00650	Small Cell Lung Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM00878	Breast Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM00254	Neuroblastoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM00875	Breast Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM01681	Non-Cancerous	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM00721	Small Cell Lung Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM00774	Breast Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM01318	Hepatocellular Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM01686	Chronic Myelogenous Leukemia	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K426R	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.2222
p.K446R	SIDM00333	Endometrial Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation substituting flanking lysine	0.3333
p.H623Y	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.1944
p.E628V	SIDM00989	Bladder Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.0556
p.E628V	BFTC-905	urinary tract	COSMIC	VVSST	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.0556
p.H495Y	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.6118
p.H495Y	RL	haematopoietic and lymphoid tissue	COSMIC	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.6118
p.H494Y	ACH-000371	Lymphoma	CCLE	RRKELHQLL	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.7229
p.E627V	ACH-000802	Bladder Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	614:618	Mutation rewiring degron network	0.0833
p.I451F	ACH-001390	Breast Cancer	CCLE	FRTMWVIGL	DEG_MDM2_SWIB_1	434:442	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PAPOLB

UniProt ID: Q9NRJ5

Entrez ID: 56903

Protein name: Poly(A) polymerase beta (PAP-beta) (EC 2.7.7.19) (Polynucleotide adenylyltransferase beta) (Testis-specific poly(A) polymerase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PAPOLB in