DegronMD

Uniprot ID: Q9NRJ5

Source protein: Poly

Source gene: PAPOLB

Class: DEG_APCC_DBOX_1

Location: 490:498

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8079

ASA_SCORE: 75.4222

COIL: 0.2973

CONS_SCORE: 0.3919

DSS_SCORE: 0.3775

HELIX: 0.611

FCONS_SCORE: 1.2327

RIG_SCORE: 0.7496

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q503H	TCGA-06-5416	GBM	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	0.1944
p.Q503H	DO10880	GBM	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	0.1944
p.G480C	TCGA-18-3407	LUSC	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	0.0556
p.G480C	DO26454	LUSC	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	0.0556
p.G480C	DO229218	THCA	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	0.0556
p.G480D	TCGA-43-7656	LUSC	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	0.0556
p.G480D	DO26424	LUSC	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	0.0556
p.I483T	TCGA-4E-A92E	UCEC	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	0.25
p.I483T	DO223277	UCEC	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	0.25
p.A485V	TCGA-AX-A2HD	UCEC	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	0.6389
p.A485V	DO42608	UCEC	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	0.6389
p.V501A	TCGA-CA-6717	COAD	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	0.25
p.V501A	DO8264	COAD	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	0.25
p.M486I	TCGA-D1-A1NY	UCEC	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	0.2222
p.M486I	DO42512	UCEC	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	0.2222
p.H500Y	TCGA-D3-A8GI	SKCM	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	0.2778
p.H500Y	TCGA-EE-A3J4	SKCM	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	0.2778
p.H500Y	DO50284	SKCM	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	0.2778
p.H500Y	DO48604	SKCM	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	0.2778
p.K482T	TCGA-EO-A22U	UCEC	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	0.1111
p.K482T	DO43755	UCEC	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	0.1111
p.P498H	TCGA-S5-A6DX	BLCA	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	0.7694
p.P498H	DO51903	BLCA	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	0.7694
p.A507S	TCGA-VQ-A91Q	STAD	TCGA	RRKELHQLL	DEG_APCC_DBOX_1	0.1944
p.A507S	DO51786	STAD	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	0.1944
p.I483F	DO50570	BOCA	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	0.25
p.K505R	DO234227	ESAD	ICGC	RRKELHQLL	DEG_APCC_DBOX_1	0.1389
p.H495Y	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRKELHQLL	DEG_APCC_DBOX_1	0.6118
p.H495Y	RL	haematopoietic_and_lymphoid_tissue	COSMIC	RRKELHQLL	DEG_APCC_DBOX_1	0.6118
p.H494Y	ACH-000371	Lymphoma	CCLE	RRKELHQLL	DEG_APCC_DBOX_1	0.7229

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRKELHQLL

Degron related mutations and impact score

Drug responses associated with PAPOLB mutations

All proteins holding degron of RRKELHQLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRJ5	Poly	DEG_APCC_DBOX_1	490:498	RRKELHQLL	APC,CDC20,FZR1	0.8079	More...