DegronMD

Uniprot ID: Q9NRJ5

Source protein: Poly

Source gene: PAPOLB

Class: DEG_SPOP_SBC_1

Location: 536:540

E3 ligase: SPOP

DEGRON score: 0.998

ASA_SCORE: 81.6

COIL: 0.9446

CONS_SCORE: 0.2226

DSS_SCORE: 0.5549

HELIX: 0.0364

FCONS_SCORE: 1.0634

RIG_SCORE: 0.6366

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S549I	TCGA-55-7907	LUAD	TCGA	VPSST	DEG_SPOP_SBC_1	0.0833
p.S549I	DO25396	LUAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.0833
p.S538Y	TCGA-A5-A2K5	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	0.712
p.S538Y	DO41379	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	0.712
p.S540I	TCGA-AJ-A3EK	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	0.7341
p.S540I	DO41584	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	0.7341
p.S532I	TCGA-AP-A1DV	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	0.2222
p.S532I	DO43186	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	0.2222
p.S549N	TCGA-D1-A0ZO	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	0.0833
p.S549N	DO41927	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	0.0833
p.S534Y	TCGA-E6-A1LX	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	0.2778
p.S534Y	DO41020	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	0.2778
p.E530Q	TCGA-GV-A3JZ	BLCA	TCGA	VPSST	DEG_SPOP_SBC_1	0.1667
p.E530Q	DO773	BLCA	ICGC	VPSST	DEG_SPOP_SBC_1	0.1667
p.A527T	TCGA-HU-A4GQ	STAD	TCGA	VPSST	DEG_SPOP_SBC_1	0.5278
p.A527T	DO47767	STAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.5278
p.S534F	DO233888	GACA	ICGC	VPSST	DEG_SPOP_SBC_1	0.2778
p.P546T	DO229027	LICA	ICGC	VPSST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43451	Maltase-glucoamylase	DEG_SPOP_SBC_1	1969:1973	VPSST	SPOP	0.5297	More...
O75509	Tumor necrosis factor receptor superfamily member 21	DEG_SPOP_SBC_1	241:245	VPSST	SPOP	0.9727	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	45:49	VPSST	SPOP	0.9082	More...
P19438	Tumor necrosis factor receptor superfamily member 1A	DEG_SPOP_SBC_1	288:292	VPSST	SPOP	0.9514	More...
Q9H1K0	Rabenosyn-5	DEG_SPOP_SBC_1	580:584	VPSST	SPOP	0.9962	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	156:160	VPSST	SPOP	0.8129	More...
Q9H4W6	Transcription factor COE3	DEG_SPOP_SBC_1	473:477	VPSST	SPOP	0.9884	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	553:557	VPSST	SPOP	0.9515	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	310:314	VPSST	SPOP	0.9925	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	1773:1777	VPSST	SPOP	0.9973	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	643:647	VPSST	SPOP	0.9721	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	536:540	VPSST	SPOP	0.998	More...
Q6ZNC4	Zinc finger protein 704	DEG_SPOP_SBC_1	121:125	VPSST	SPOP	0.9625	More...
Q96LR7	Uncharacterized protein C2orf50	DEG_SPOP_SBC_1	119:123	VPSST	SPOP	0.8932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons