DegronMD - Q96LR7(C2orf50)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P109S	TCGA-A6-5661	COAD	TCGA	VPSST	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.0556
p.P109S	TCGA-A6-5661	COAD	TCGA	VPLFSD	LIG_APCC_ABBA_1	112:117	Mutation rewiring degron network	0.25
p.P109S	DO8634	COAD	ICGC	VPSST	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.0556
p.P109S	DO8634	COAD	ICGC	VPLFSD	LIG_APCC_ABBA_1	112:117	Mutation rewiring degron network	0.25
p.S129N	TCGA-AN-A0AK	BRCA	TCGA	VPSST	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1667
p.S129N	DO1608	BRCA	ICGC	VPSST	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1667
p.D132G	TCGA-B5-A3FA	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.0833
p.D132G	DO52402	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.0833
p.S116L	TCGA-D1-A17Q	UCEC	TCGA	VPLFSD	LIG_APCC_ABBA_1	112:117	Mutation altering degron motif	0.6556
p.S116L	TCGA-Q1-A73O	CESC	TCGA	VPLFSD	LIG_APCC_ABBA_1	112:117	Mutation altering degron motif	0.6556
p.S116L	DO51612	CESC	ICGC	VPLFSD	LIG_APCC_ABBA_1	112:117	Mutation altering degron motif	0.6556
p.S116L	DO41903	UCEC	ICGC	VPLFSD	LIG_APCC_ABBA_1	112:117	Mutation altering degron motif	0.6556
p.P120L	TCGA-FW-A3R5	SKCM	TCGA	VPSST	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.6471
p.P120L	DO37406	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.6471
p.S27L	DO227587	COCA	ICGC	RPPASVSPA	DEG_SIAH_1	23:31	Mutation altering degron motif	0.6556
p.E104D	DO229018	LICA	ICGC	VPLFSD	LIG_APCC_ABBA_1	112:117	Mutation rewiring degron network	0.1111
p.G34C	SIDM00507	Other Solid Cancers	GDSC	RPPASVSPA	DEG_SIAH_1	23:31	Mutation rewiring degron network	0.25
p.G34C	ACH-001490	Lung Cancer	CCLE	RPPASVSPA	DEG_SIAH_1	23:31	Mutation rewiring degron network	0.25
p.D117N	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VPLFSD	LIG_APCC_ABBA_1	112:117	Mutation altering degron motif	0.6932
p.D117N	ACH-000929	Lung Cancer	CCLE	VPLFSD	LIG_APCC_ABBA_1	112:117	Mutation altering degron motif	0.6932
p.P21H	ACH-001318	Liver Cancer	CCLE	RPPASVSPA	DEG_SIAH_1	23:31	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C2orf50

UniProt ID: Q96LR7

Entrez ID: 130813

Protein name: Uncharacterized protein C2orf50

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C2orf50 in