DegronMD

Uniprot ID: Q96LR7

Source protein: Uncharacterized protein C2orf50

Source gene: C2orf50

Class: DEG_SIAH_1

Location: 23:31

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.8558

ASA_SCORE: 70.0667

COIL: 0.8452

CONS_SCORE: 0.6588

DSS_SCORE: 0.6934

HELIX: 0.1236

FCONS_SCORE: 0.9251

RIG_SCORE: 0.6244

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S27L	DO227587	COCA	ICGC	RPPASVSPA	DEG_SIAH_1	0.6556
p.P21H	ACH-001318	Liver Cancer	CCLE	RPPASVSPA	DEG_SIAH_1	0.2778
p.G34C	SIDM00507	Other Solid Cancers	GDSC	RPPASVSPA	DEG_SIAH_1	0.25
p.G34C	ACH-001490	Lung Cancer	CCLE	RPPASVSPA	DEG_SIAH_1	0.25

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96LR7	Uncharacterized protein C2orf50	DEG_SIAH_1	23:31	RPPASVSPA	SIAH1,SIAH2,SIAH3	0.8558	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons