DegronMD

Uniprot ID: Q96LR7

Source protein: Uncharacterized protein C2orf50

Source gene: C2orf50

Class: LIG_APCC_ABBA_1

Location: 112:117

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9907

ASA_SCORE: 69.6833

COIL: 0.8792

CONS_SCORE: 0.8407

DSS_SCORE: 0.5276

HELIX: 0.0447

FCONS_SCORE: 1.0184

RIG_SCORE: 0.7213

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P109S	TCGA-A6-5661	COAD	TCGA	VPLFSD	LIG_APCC_ABBA_1	0.25
p.P109S	DO8634	COAD	ICGC	VPLFSD	LIG_APCC_ABBA_1	0.25
p.S116L	TCGA-D1-A17Q	UCEC	TCGA	VPLFSD	LIG_APCC_ABBA_1	0.6556
p.S116L	TCGA-Q1-A73O	CESC	TCGA	VPLFSD	LIG_APCC_ABBA_1	0.6556
p.S116L	DO51612	CESC	ICGC	VPLFSD	LIG_APCC_ABBA_1	0.6556
p.S116L	DO41903	UCEC	ICGC	VPLFSD	LIG_APCC_ABBA_1	0.6556
p.E104D	DO229018	LICA	ICGC	VPLFSD	LIG_APCC_ABBA_1	0.1111
p.D117N	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VPLFSD	LIG_APCC_ABBA_1	0.6932
p.D117N	ACH-000929	Lung Cancer	CCLE	VPLFSD	LIG_APCC_ABBA_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96LR7	Uncharacterized protein C2orf50	LIG_APCC_ABBA_1	112:117	VPLFSD	APC,CDC20,FZR1	0.9907	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons