DegronMD

Uniprot ID: O75509

Source protein: Tumor necrosis factor receptor superfamily member 21

Source gene: TNFRSF21

Class: DEG_SPOP_SBC_1

Location: 241:245

E3 ligase: SPOP

DEGRON score: 0.9727

ASA_SCORE: 65.22

COIL: 0.709

CONS_SCORE: 0.6569

DSS_SCORE: 0.65

HELIX: 0.0344

FCONS_SCORE: 1.0305

RIG_SCORE: 0.6656

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V241F	TCGA-86-8358	LUAD	TCGA	VPSST	DEG_SPOP_SBC_1	0.7068
p.V241F	DO25471	LUAD	ICGC	VPSST	DEG_SPOP_SBC_1	0.7068
p.P231L	TCGA-BF-A5EO	SKCM	TCGA	VPSST	DEG_SPOP_SBC_1	0.0556
p.P231L	DO219450	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	0.0556
p.M236I	TCGA-CN-6010	HNSC	TCGA	VPSST	DEG_SPOP_SBC_1	0.1944
p.M236I	DO14766	HNSC	ICGC	VPSST	DEG_SPOP_SBC_1	0.1944
p.P242S	TCGA-D6-6516	HNSC	TCGA	VPSST	DEG_SPOP_SBC_1	0.5641
p.P242S	TCGA-W3-A825	SKCM	TCGA	VPSST	DEG_SPOP_SBC_1	0.5641
p.P242S	DO15623	HNSC	ICGC	VPSST	DEG_SPOP_SBC_1	0.5641
p.P242S	DO51272	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	0.5641
p.P248L	TCGA-EE-A20C	SKCM	TCGA	VPSST	DEG_SPOP_SBC_1	0.25
p.P248L	DO222775	MELA	ICGC	VPSST	DEG_SPOP_SBC_1	0.25
p.P248L	DO222702	MELA	ICGC	VPSST	DEG_SPOP_SBC_1	0.25
p.P248L	DO47665	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	0.25
p.E240K	TCGA-OD-A75X	SKCM	TCGA	VPSST	DEG_SPOP_SBC_1	0.3056
p.E240K	DO48601	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	0.3056
p.H235Q	DO229019	LICA	ICGC	VPSST	DEG_SPOP_SBC_1	0.1667
p.P242L	DO220903	MELA	ICGC	VPSST	DEG_SPOP_SBC_1	0.6471
p.V247D	SIDM00162	Biliary Tract Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	0.2778
p.V247D	ACH-000268	Bile Duct Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	0.2778
p.R232L	ACH-001032	Bone Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	0.0833
p.R232C	ACH-001128	Rhabdoid	CCLE	VPSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43451	Maltase-glucoamylase	DEG_SPOP_SBC_1	1969:1973	VPSST	SPOP	0.5297	More...
O75509	Tumor necrosis factor receptor superfamily member 21	DEG_SPOP_SBC_1	241:245	VPSST	SPOP	0.9727	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	45:49	VPSST	SPOP	0.9082	More...
P19438	Tumor necrosis factor receptor superfamily member 1A	DEG_SPOP_SBC_1	288:292	VPSST	SPOP	0.9514	More...
Q9H1K0	Rabenosyn-5	DEG_SPOP_SBC_1	580:584	VPSST	SPOP	0.9962	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	156:160	VPSST	SPOP	0.8129	More...
Q9H4W6	Transcription factor COE3	DEG_SPOP_SBC_1	473:477	VPSST	SPOP	0.9884	More...
Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	DEG_SPOP_SBC_1	553:557	VPSST	SPOP	0.9515	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	310:314	VPSST	SPOP	0.9925	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	1773:1777	VPSST	SPOP	0.9973	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	643:647	VPSST	SPOP	0.9721	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	536:540	VPSST	SPOP	0.998	More...
Q6ZNC4	Zinc finger protein 704	DEG_SPOP_SBC_1	121:125	VPSST	SPOP	0.9625	More...
Q96LR7	Uncharacterized protein C2orf50	DEG_SPOP_SBC_1	119:123	VPSST	SPOP	0.8932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons