DegronMD - O75509(TNFRSF21)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V241F	TCGA-86-8358	LUAD	TCGA	VPSST	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.7068
p.V241F	DO25471	LUAD	ICGC	VPSST	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.7068
p.S8I	TCGA-AA-A010	COAD	TCGA	PSSST	DEG_SPOP_SBC_1	5:9	Mutation altering degron motif	0.7341
p.P231L	TCGA-BF-A5EO	SKCM	TCGA	VPSST	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.0556
p.P231L	DO219450	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.0556
p.M236I	TCGA-CN-6010	HNSC	TCGA	VPSST	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.1944
p.M236I	DO14766	HNSC	ICGC	VPSST	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.1944
p.P242S	TCGA-D6-6516	HNSC	TCGA	VPSST	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.5641
p.P242S	TCGA-W3-A825	SKCM	TCGA	VPSST	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.5641
p.P242S	DO15623	HNSC	ICGC	VPSST	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.5641
p.P242S	DO51272	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.5641
p.P248L	TCGA-EE-A20C	SKCM	TCGA	VPSST	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.25
p.P248L	DO222775	MELA	ICGC	VPSST	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.25
p.P248L	DO222702	MELA	ICGC	VPSST	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.25
p.P248L	DO47665	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.25
p.E240K	TCGA-OD-A75X	SKCM	TCGA	VPSST	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.3056
p.E240K	DO48601	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.3056
p.H235Q	DO229019	LICA	ICGC	VPSST	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.1667
p.P242L	DO220903	MELA	ICGC	VPSST	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.6471
p.V247D	SIDM00162	Biliary Tract Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.2778
p.V247D	ACH-000268	Bile Duct Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.2778
p.R232L	ACH-001032	Bone Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.0833
p.R232C	ACH-001128	Rhabdoid	CCLE	VPSST	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.0833

Kaplan plot for TNFRSF21 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNFRSF21

UniProt ID: O75509

Entrez ID: 27242

Protein name: Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNFRSF21 in