DegronMD - Q6ZNC4(ZNF704)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E47K	TCGA-55-8204	LUAD	TCGA	EKENT	DEG_APCC_KENBOX_2	47:51	Mutation altering degron motif	0.591
p.E47K	DO45322	LUAD	ICGC	EKENT	DEG_APCC_KENBOX_2	47:51	Mutation altering degron motif	0.591
p.A40V	TCGA-AN-A046	BRCA	TCGA	EKENT	DEG_APCC_KENBOX_2	47:51	Mutation rewiring degron network	0.1389
p.A40V	DO1285	BRCA	ICGC	EKENT	DEG_APCC_KENBOX_2	47:51	Mutation rewiring degron network	0.1389
p.L56F	TCGA-D3-A2JL	SKCM	TCGA	EKENT	DEG_APCC_KENBOX_2	47:51	Mutation rewiring degron network	0.1944
p.L56F	DO47278	SKCM	ICGC	EKENT	DEG_APCC_KENBOX_2	47:51	Mutation rewiring degron network	0.1944
p.L57F	TCGA-EE-A2MS	SKCM	TCGA	EKENT	DEG_APCC_KENBOX_2	47:51	Mutation rewiring degron network	0.1667
p.L57F	DO46827	RECA	ICGC	EKENT	DEG_APCC_KENBOX_2	47:51	Mutation rewiring degron network	0.1667
p.L57F	DO37567	SKCM	ICGC	EKENT	DEG_APCC_KENBOX_2	47:51	Mutation rewiring degron network	0.1667
p.H46Y	DO229505	LAML	ICGC	EKENT	DEG_APCC_KENBOX_2	47:51	Mutation rewiring degron network	0.3056
p.H46Y	SIDM00437	Acute Myeloid Leukemia	GDSC	EKENT	DEG_APCC_KENBOX_2	47:51	Mutation rewiring degron network	0.3056
p.H46Y	SIDM00489	Oral Cavity Carcinoma	GDSC	EKENT	DEG_APCC_KENBOX_2	47:51	Mutation rewiring degron network	0.3056
p.H46Y	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	EKENT	DEG_APCC_KENBOX_2	47:51	Mutation rewiring degron network	0.3056
p.G129C	DO229043	LICA	ICGC	VPSST	DEG_SPOP_SBC_1	121:125	Mutation rewiring degron network	0.2222
p.R61G	DO27279	LUSC	ICGC	EKENT	DEG_APCC_KENBOX_2	47:51	Mutation rewiring degron network	0.0556
p.S112R	DO232043	ORCA	ICGC	VPSST	DEG_SPOP_SBC_1	121:125	Mutation rewiring degron network	0.0833
p.L111I	ACH-000943	Colon/Colorectal Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	121:125	Mutation rewiring degron network	0.0556

Kaplan plot for ZNF704 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF704

UniProt ID: Q6ZNC4

Entrez ID: 619279

Protein name: Zinc finger protein 704

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZNF704 in