DegronMD

Uniprot ID: Q6ZNC4

Source protein: Zinc finger protein 704

Source gene: ZNF704

Class: DEG_APCC_KENBOX_2

Location: 47:51

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7426

ASA_SCORE: 96.48

COIL: 0.6966

CONS_SCORE: 0.4199

DSS_SCORE: 0.3991

HELIX: 0.2732

FCONS_SCORE: 0.9801

RIG_SCORE: 0.772

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E47K	TCGA-55-8204	LUAD	TCGA	EKENT	DEG_APCC_KENBOX_2	0.591
p.E47K	DO45322	LUAD	ICGC	EKENT	DEG_APCC_KENBOX_2	0.591
p.A40V	TCGA-AN-A046	BRCA	TCGA	EKENT	DEG_APCC_KENBOX_2	0.1389
p.A40V	DO1285	BRCA	ICGC	EKENT	DEG_APCC_KENBOX_2	0.1389
p.L56F	TCGA-D3-A2JL	SKCM	TCGA	EKENT	DEG_APCC_KENBOX_2	0.1944
p.L56F	DO47278	SKCM	ICGC	EKENT	DEG_APCC_KENBOX_2	0.1944
p.L57F	TCGA-EE-A2MS	SKCM	TCGA	EKENT	DEG_APCC_KENBOX_2	0.1667
p.L57F	DO46827	RECA	ICGC	EKENT	DEG_APCC_KENBOX_2	0.1667
p.L57F	DO37567	SKCM	ICGC	EKENT	DEG_APCC_KENBOX_2	0.1667
p.H46Y	DO229505	LAML	ICGC	EKENT	DEG_APCC_KENBOX_2	0.3056
p.H46Y	SIDM00437	Acute Myeloid Leukemia	GDSC	EKENT	DEG_APCC_KENBOX_2	0.3056
p.H46Y	SIDM00489	Oral Cavity Carcinoma	GDSC	EKENT	DEG_APCC_KENBOX_2	0.3056
p.H46Y	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	EKENT	DEG_APCC_KENBOX_2	0.3056
p.R61G	DO27279	LUSC	ICGC	EKENT	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7C8	Transcription initiation factor TFIID subunit 8	DEG_APCC_KENBOX_2	266:270	EKENT	APC,CDC20,FZR1	0.9531	More...
Q9NYW8	RB-associated KRAB zinc finger protein	DEG_APCC_KENBOX_2	113:117	EKENT	APC,CDC20,FZR1	0.9717	More...
Q6ZNC4	Zinc finger protein 704	DEG_APCC_KENBOX_2	47:51	EKENT	APC,CDC20,FZR1	0.7426	More...
Q9BVR0	Putative HERC2-like protein 3	DEG_APCC_KENBOX_2	1148:1152	EKENT	APC,CDC20,FZR1	0.6285	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons