DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
EKENT
Uniprot ID:
Q9BVR0
Source protein:
Putative HERC2-like protein 3
Source gene:
HERC2P3
Class:
DEG_APCC_KENBOX_2
Location:
1148:1152
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6285
ASA_SCORE:
121.4
COIL:
0.718
CONS_SCORE:
0.0125
DSS_SCORE:
0.4294
HELIX:
0.2568
FCONS_SCORE:
1
RIG_SCORE:
0.7526
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with HERC2P3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of EKENT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z7C8
Transcription initiation factor TFIID subunit 8
DEG_APCC_KENBOX_2
266:270
EKENT
APC,CDC20,FZR1
0.9531
More...
Q9NYW8
RB-associated KRAB zinc finger protein
DEG_APCC_KENBOX_2
113:117
EKENT
APC,CDC20,FZR1
0.9717
More...
Q6ZNC4
Zinc finger protein 704
DEG_APCC_KENBOX_2
47:51
EKENT
APC,CDC20,FZR1
0.7426
More...
Q9BVR0
Putative HERC2-like protein 3
DEG_APCC_KENBOX_2
1148:1152
EKENT
APC,CDC20,FZR1
0.6285
More...