DegronMD - Q9NYW8(RBAK)

RBAK

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E115Q	TCGA-D8-A1J9	BRCA	TCGA	EKENT	DEG_APCC_KENBOX_2	113:117	Mutation altering degron motif	0.6744
p.E115Q	DO2067	BRCA	ICGC	EKENT	DEG_APCC_KENBOX_2	113:117	Mutation altering degron motif	0.6744
p.T111S	DO227844	COCA	ICGC	EKENT	DEG_APCC_KENBOX_2	113:117	Mutation rewiring degron network	0.2778
p.T111S	SIDM00087	Plasma Cell Myeloma	GDSC	EKENT	DEG_APCC_KENBOX_2	113:117	Mutation rewiring degron network	0.2778
p.T111S	ACH-000817	Myeloma	CCLE	EKENT	DEG_APCC_KENBOX_2	113:117	Mutation rewiring degron network	0.2778
p.T111S	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	EKENT	DEG_APCC_KENBOX_2	113:117	Mutation rewiring degron network	0.2778
p.T117A	DO233784	GACA	ICGC	EKENT	DEG_APCC_KENBOX_2	113:117	Mutation altering degron motif	0.6028
p.C104F	DO229019	LICA	ICGC	EKENT	DEG_APCC_KENBOX_2	113:117	Mutation rewiring degron network	0.0833
p.C104F	DO229038	LICA	ICGC	EKENT	DEG_APCC_KENBOX_2	113:117	Mutation rewiring degron network	0.0833
p.L127F	SIDM00541	Colorectal Carcinoma	GDSC	EKENT	DEG_APCC_KENBOX_2	113:117	Mutation rewiring degron network	0.0556
p.L127F	ACH-000926	Colon/Colorectal Cancer	CCLE	EKENT	DEG_APCC_KENBOX_2	113:117	Mutation rewiring degron network	0.0556
p.L127F	HT55	large intestine	COSMIC	EKENT	DEG_APCC_KENBOX_2	113:117	Mutation rewiring degron network	0.0556
p.N106S	SIDM00878	Breast Carcinoma	GDSC	EKENT	DEG_APCC_KENBOX_2	113:117	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc