DegronMD

Uniprot ID: Q9NYW8

Source protein: RB-associated KRAB zinc finger protein

Source gene: RBAK

Class: DEG_APCC_KENBOX_2

Location: 113:117

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9717

ASA_SCORE: 101.84

COIL: 0.7704

CONS_SCORE: 0.2912

DSS_SCORE: 0.3551

HELIX: 0.1422

FCONS_SCORE: 0.8383

RIG_SCORE: 0.7937

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E115Q	TCGA-D8-A1J9	BRCA	TCGA	EKENT	DEG_APCC_KENBOX_2	0.6744
p.E115Q	DO2067	BRCA	ICGC	EKENT	DEG_APCC_KENBOX_2	0.6744
p.T111S	DO227844	COCA	ICGC	EKENT	DEG_APCC_KENBOX_2	0.2778
p.T111S	SIDM00087	Plasma Cell Myeloma	GDSC	EKENT	DEG_APCC_KENBOX_2	0.2778
p.T111S	ACH-000817	Myeloma	CCLE	EKENT	DEG_APCC_KENBOX_2	0.2778
p.T111S	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	EKENT	DEG_APCC_KENBOX_2	0.2778
p.T117A	DO233784	GACA	ICGC	EKENT	DEG_APCC_KENBOX_2	0.6028
p.C104F	DO229019	LICA	ICGC	EKENT	DEG_APCC_KENBOX_2	0.0833
p.C104F	DO229038	LICA	ICGC	EKENT	DEG_APCC_KENBOX_2	0.0833
p.L127F	SIDM00541	Colorectal Carcinoma	GDSC	EKENT	DEG_APCC_KENBOX_2	0.0556
p.L127F	ACH-000926	Colon/Colorectal Cancer	CCLE	EKENT	DEG_APCC_KENBOX_2	0.0556
p.L127F	HT55	large_intestine	COSMIC	EKENT	DEG_APCC_KENBOX_2	0.0556
p.N106S	SIDM00878	Breast Carcinoma	GDSC	EKENT	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7C8	Transcription initiation factor TFIID subunit 8	DEG_APCC_KENBOX_2	266:270	EKENT	APC,CDC20,FZR1	0.9531	More...
Q9NYW8	RB-associated KRAB zinc finger protein	DEG_APCC_KENBOX_2	113:117	EKENT	APC,CDC20,FZR1	0.9717	More...
Q6ZNC4	Zinc finger protein 704	DEG_APCC_KENBOX_2	47:51	EKENT	APC,CDC20,FZR1	0.7426	More...
Q9BVR0	Putative HERC2-like protein 3	DEG_APCC_KENBOX_2	1148:1152	EKENT	APC,CDC20,FZR1	0.6285	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons