DegronMD

Uniprot ID: Q7Z7C8

Source protein: Transcription initiation factor TFIID subunit 8

Source gene: TAF8

Class: DEG_APCC_KENBOX_2

Location: 266:270

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9531

ASA_SCORE: 105.98

COIL: 0.5926

CONS_SCORE: 0.5645

DSS_SCORE: 0.7121

HELIX: 0.3748

FCONS_SCORE: 1.0084

RIG_SCORE: 0.6578

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N276K	TCGA-39-5035	LUSC	TCGA	EKENT	DEG_APCC_KENBOX_2	0.1667
p.Q274R	TCGA-AP-A1DK	UCEC	TCGA	EKENT	DEG_APCC_KENBOX_2	0.2222
p.S263Y	TCGA-CA-6717	COAD	TCGA	EKENT	DEG_APCC_KENBOX_2	0.25
p.K267E	TCGA-D5-6930	COAD	TCGA	EKENT	DEG_APCC_KENBOX_2	0.7022
p.K267E	DO10550	COAD	ICGC	EKENT	DEG_APCC_KENBOX_2	0.7022
p.E268D	TCGA-Y8-A8RZ	KIRP	TCGA	EKENT	DEG_APCC_KENBOX_2	0.6758
p.E268D	DO49807	KIRP	ICGC	EKENT	DEG_APCC_KENBOX_2	0.6758
p.N269Y	TCGA-Y8-A8RZ	KIRP	TCGA	EKENT	DEG_APCC_KENBOX_2	0.7059
p.E266K	DO233089	GACA	ICGC	EKENT	DEG_APCC_KENBOX_2	0.591
p.E266K	DO228948	LICA	ICGC	EKENT	DEG_APCC_KENBOX_2	0.591
p.E261D	DO228974	LICA	ICGC	EKENT	DEG_APCC_KENBOX_2	0.1944
p.S278A	SIDM00003	Melanoma	GDSC	EKENT	DEG_APCC_KENBOX_2	0.5556
p.S278A	M14	skin	COSMIC	EKENT	DEG_APCC_KENBOX_2	0.5556
p.S280L	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	EKENT	DEG_APCC_KENBOX_2	0.0556
p.S280L	SIDM00736	Non-Cancerous	GDSC	EKENT	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7C8	Transcription initiation factor TFIID subunit 8	DEG_APCC_KENBOX_2	266:270	EKENT	APC,CDC20,FZR1	0.9531	More...
Q9NYW8	RB-associated KRAB zinc finger protein	DEG_APCC_KENBOX_2	113:117	EKENT	APC,CDC20,FZR1	0.9717	More...
Q6ZNC4	Zinc finger protein 704	DEG_APCC_KENBOX_2	47:51	EKENT	APC,CDC20,FZR1	0.7426	More...
Q9BVR0	Putative HERC2-like protein 3	DEG_APCC_KENBOX_2	1148:1152	EKENT	APC,CDC20,FZR1	0.6285	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons