DegronMD - P19438(TNFRSF1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P277A	TCGA-BH-A0B6	BRCA	TCGA	PTPGFT	DEG_SCF_FBW7_1	275:280	Mutation altering degron motif	0.7503
p.P269T	TCGA-D9-A148	SKCM	TCGA	PTPGFT	DEG_SCF_FBW7_1	275:280	Mutation rewiring degron network	0.1667
p.V288M	TCGA-EO-A22S	UCEC	TCGA	VPSST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.7208
p.V288M	SIDM01245	T-Lymphoblastic Leukemia	GDSC	VPSST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.7208
p.V288M	SIDM00991	T-Lymphoblastic Leukemia	GDSC	VPSST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.7208
p.V288M	ACH-000519	Leukemia	CCLE	VPSST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.7208
p.V288M	ACH-002216	Leukemia	CCLE	VPSST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.7208
p.V288M	BE-13	haematopoietic and lymphoid tissue	COSMIC	VPSST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.7208
p.F273L	TCGA-F7-A624	HNSC	TCGA	PTPGFT	DEG_SCF_FBW7_1	275:280	Mutation rewiring degron network	0.2778
p.P289A	TCGA-OR-A5LP	ACC	TCGA	VPSST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.6392
p.R269T	DO44029	BLCA	ICGC	PTPGFT	DEG_SCF_FBW7_1	275:280	Mutation rewiring degron network	0.1667
p.R269K	DO219052	BLCA	ICGC	PTPGFT	DEG_SCF_FBW7_1	275:280	Mutation rewiring degron network	0.1667
p.A283V	DO223732	CESC	ICGC	PTPGFT	DEG_SCF_FBW7_1	275:280	Mutation rewiring degron network	0.25
p.A283V	DO223732	CESC	ICGC	VPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1944
p.A283V	DO227976	COCA	ICGC	PTPGFT	DEG_SCF_FBW7_1	275:280	Mutation rewiring degron network	0.25
p.A283V	DO227976	COCA	ICGC	VPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1944
p.P267S	DO49004	CESC	ICGC	PTPGFT	DEG_SCF_FBW7_1	275:280	Mutation rewiring degron network	0.1111
p.Q276L	DO228643	GACA	ICGC	PTPGFT	DEG_SCF_FBW7_1	275:280	Mutation altering degron motif	0.7765
p.L286F	DO45089	LINC	ICGC	PTPGFT	DEG_SCF_FBW7_1	275:280	Mutation rewiring degron network	0.1667
p.L286F	DO45089	LINC	ICGC	VPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.2778
p.W298G	DO45197	LIRI	ICGC	VPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1667
p.P267L	DO50288	SKCM	ICGC	PTPGFT	DEG_SCF_FBW7_1	275:280	Mutation rewiring degron network	0.1111
p.L295I	DO37986	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.25
p.P294L	DO51294	SKCM	ICGC	VPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.2778
p.P294A	DO229208	THCA	ICGC	VPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.2778
p.A285T	DO40879	UCEC	ICGC	PTPGFT	DEG_SCF_FBW7_1	275:280	Mutation rewiring degron network	0.1944
p.A285T	DO40879	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.25
p.P275S	SIDM01118	Small Cell Lung Carcinoma	GDSC	PTPGFT	DEG_SCF_FBW7_1	275:280	Mutation altering degron motif	0.6752
p.P275S	ACH-002175	Lung Cancer	CCLE	PTPGFT	DEG_SCF_FBW7_1	275:280	Mutation altering degron motif	0.6752
p.P275S	NCI-H740	lung	COSMIC	PTPGFT	DEG_SCF_FBW7_1	275:280	Mutation altering degron motif	0.6752
p.G302S	ACH-001737	Leukemia	CCLE	VPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.0556

Kaplan plot for TNFRSF1A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNFRSF1A

UniProt ID: P19438

Entrez ID: 7132

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNFRSF1A in