DegronMD

Uniprot ID: P19438

Source protein: Tumor necrosis factor receptor superfamily member 1A

Source gene: TNFRSF1A

Class: DEG_SCF_FBW7_1

Location: 275:280

E3 ligase: FBXW7

DEGRON score: 0.9977

ASA_SCORE: 77.0333

COIL: 0.9365

CONS_SCORE: 0.6406

DSS_SCORE: 0.5759

HELIX: 0.0205

FCONS_SCORE: 1.139

RIG_SCORE: 0.6365

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P277A	TCGA-BH-A0B6	BRCA	TCGA	PTPGFT	DEG_SCF_FBW7_1	0.7503
p.P269T	TCGA-D9-A148	SKCM	TCGA	PTPGFT	DEG_SCF_FBW7_1	0.1667
p.F273L	TCGA-F7-A624	HNSC	TCGA	PTPGFT	DEG_SCF_FBW7_1	0.2778
p.R269T	DO44029	BLCA	ICGC	PTPGFT	DEG_SCF_FBW7_1	0.1667
p.R269K	DO219052	BLCA	ICGC	PTPGFT	DEG_SCF_FBW7_1	0.1667
p.A283V	DO223732	CESC	ICGC	PTPGFT	DEG_SCF_FBW7_1	0.25
p.A283V	DO227976	COCA	ICGC	PTPGFT	DEG_SCF_FBW7_1	0.25
p.P267S	DO49004	CESC	ICGC	PTPGFT	DEG_SCF_FBW7_1	0.1111
p.Q276L	DO228643	GACA	ICGC	PTPGFT	DEG_SCF_FBW7_1	0.7765
p.L286F	DO45089	LINC	ICGC	PTPGFT	DEG_SCF_FBW7_1	0.1667
p.P267L	DO50288	SKCM	ICGC	PTPGFT	DEG_SCF_FBW7_1	0.1111
p.A285T	DO40879	UCEC	ICGC	PTPGFT	DEG_SCF_FBW7_1	0.1944
p.P275S	SIDM01118	Small Cell Lung Carcinoma	GDSC	PTPGFT	DEG_SCF_FBW7_1	0.6752
p.P275S	ACH-002175	Lung Cancer	CCLE	PTPGFT	DEG_SCF_FBW7_1	0.6752
p.P275S	NCI-H740	lung	COSMIC	PTPGFT	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19438	Tumor necrosis factor receptor superfamily member 1A	DEG_SCF_FBW7_1	275:280	PTPGFT	FBXW7	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons