DegronMD

Uniprot ID: Q9NRJ5

Source protein: Poly

Source gene: PAPOLB

Class: DEG_MDM2_SWIB_1

Location: 434:442

E3 ligase: MDM2

DEGRON score: 0.6437

ASA_SCORE: 19.8222

COIL: 0.1106

CONS_SCORE: 0.4816

DSS_SCORE: 0.2794

HELIX: 0.0171

FCONS_SCORE: 1.9389

RIG_SCORE: 0.8881

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P428S	TCGA-AP-A1DV	UCEC	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	0.1667
p.P428S	DO43186	UCEC	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.1667
p.E426G	TCGA-B5-A11E	UCEC	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.E426G	DO41644	UCEC	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.L452F	TCGA-EO-A3AV	UCEC	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	0.0556
p.L452F	DO52412	UCEC	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.0556
p.M436I	TCGA-FV-A496	LIHC	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	0.7618
p.M436I	DO44966	LIHC	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.7618
p.W437R	TCGA-VS-A9UO	CESC	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	0.8634
p.W437R	DO219736	CESC	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.8634
p.M431V	SIDM01137	Pancreatic Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.25
p.M431V	PANC-04-03	pancreas	COSMIC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.25
p.K426R	SIDM00933	Breast Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM00773	Non-Cancerous	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM00855	Other Sarcomas	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM00654	Small Cell Lung Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM00529	Breast Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM00650	Small Cell Lung Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM00878	Breast Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM00254	Neuroblastoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM00875	Breast Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM01681	Non-Cancerous	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM00721	Small Cell Lung Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM00774	Breast Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM01318	Hepatocellular Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM01686	Chronic Myelogenous Leukemia	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K426R	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.K446R	SIDM00333	Endometrial Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.3333
p.I451F	ACH-001390	Breast Cancer	CCLE	FRTMWVIGL	DEG_MDM2_SWIB_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FRTMWVIGL

Degron related mutations and impact score

Drug responses associated with PAPOLB mutations

All proteins holding degron of FRTMWVIGL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51003	Poly	DEG_MDM2_SWIB_1	433:441	FRTMWVIGL	MDM2	0.5198	More...
Q9NRJ5	Poly	DEG_MDM2_SWIB_1	434:442	FRTMWVIGL	MDM2	0.6437	More...