DegronMD

Uniprot ID: P51003

Source protein: Poly

Source gene: PAPOLA

Class: DEG_MDM2_SWIB_1

Location: 433:441

E3 ligase: MDM2

DEGRON score: 0.5198

ASA_SCORE: 21.3667

COIL: 0.123

CONS_SCORE: 0.4309

DSS_SCORE: 0.2387

HELIX: 0.0134

FCONS_SCORE: 1.7701

RIG_SCORE: 0.91

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R434C	TCGA-AJ-A3EL	UCEC	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	0.719
p.R434C	TCGA-BR-8680	STAD	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	0.719
p.R434C	DO47769	STAD	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.719
p.R434C	DO41542	UCEC	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.719
p.W437L	TCGA-D3-A2J8	SKCM	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	0.7015
p.W437L	DO37778	SKCM	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.7015
p.N451T	TCGA-D5-6531	COAD	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	0.0556
p.N451T	DO7983	COAD	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.0556
p.E426K	TCGA-DK-A3X1	BLCA	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	0.1389
p.E426K	DO447	BLCA	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.1389
p.A423T	TCGA-DU-6392	LGG	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	0.0556
p.A423T	DO22237	LGG	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.0556
p.P428L	TCGA-SL-A6JA	UCEC	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	0.1944
p.P428L	DO219787	UCEC	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.1944
p.D429N	DO234243	ESAD	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.2222
p.M436I	DO229018	LICA	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.6507
p.R434S	SIDM00212	Glioblastoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.6316
p.R434S	ACH-000464	Brain Cancer	CCLE	FRTMWVIGL	DEG_MDM2_SWIB_1	0.6316
p.R434S	CAS-1	central_nervous_system	COSMIC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.6316
p.E432Q	SIDM00414	Bladder Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.3056
p.E432Q	ACH-000545	Bladder Cancer	CCLE	FRTMWVIGL	DEG_MDM2_SWIB_1	0.3056
p.E432Q	VM-CUB-1	urinary_tract	COSMIC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.3056
p.T435M	SIDM00980	Gastric Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.6312
p.T435M	ACH-000948	Gastric Cancer	CCLE	FRTMWVIGL	DEG_MDM2_SWIB_1	0.6312
p.T435M	ACH-001622	Brain Cancer	CCLE	FRTMWVIGL	DEG_MDM2_SWIB_1	0.6312
p.T435M	23132-87	stomach	COSMIC	FRTMWVIGL	DEG_MDM2_SWIB_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51003	Poly	DEG_MDM2_SWIB_1	433:441	FRTMWVIGL	MDM2	0.5198	More...
Q9NRJ5	Poly	DEG_MDM2_SWIB_1	434:442	FRTMWVIGL	MDM2	0.6437	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FRTMWVIGL

Degron related mutations and impact score

Drug responses associated with PAPOLA mutations

All proteins holding degron of FRTMWVIGL