DegronMD - P51003(PAPOLA)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D524A	TCGA-39-5030	LUSC	TCGA	DSDNSMSVPSP	DEG_COP1_1	528:538	Mutation rewiring degron network	0.2222
p.D524A	DO27176	LUSC	ICGC	DSDNSMSVPSP	DEG_COP1_1	528:538	Mutation rewiring degron network	0.2222
p.R434C	TCGA-AJ-A3EL	UCEC	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation altering degron motif	0.719
p.R434C	TCGA-BR-8680	STAD	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation altering degron motif	0.719
p.R434C	DO47769	STAD	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation altering degron motif	0.719
p.R434C	DO41542	UCEC	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation altering degron motif	0.719
p.R620C	TCGA-CK-6748	COAD	TCGA	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.3056
p.R620C	DO7816	COAD	ICGC	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.3056
p.P610S	TCGA-CR-7371	HNSC	TCGA	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1944
p.P610S	DO15454	HNSC	ICGC	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1944
p.D524N	TCGA-D1-A17Q	UCEC	TCGA	DSDNSMSVPSP	DEG_COP1_1	528:538	Mutation rewiring degron network	0.2222
p.D524N	TCGA-IB-7651	PAAD	TCGA	DSDNSMSVPSP	DEG_COP1_1	528:538	Mutation rewiring degron network	0.2222
p.D524N	DO46657	PAAD	ICGC	DSDNSMSVPSP	DEG_COP1_1	528:538	Mutation rewiring degron network	0.2222
p.D524N	DO41903	UCEC	ICGC	DSDNSMSVPSP	DEG_COP1_1	528:538	Mutation rewiring degron network	0.2222
p.W437L	TCGA-D3-A2J8	SKCM	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation altering degron motif	0.7015
p.W437L	DO37778	SKCM	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation altering degron motif	0.7015
p.N451T	TCGA-D5-6531	COAD	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation rewiring degron network	0.0556
p.N451T	DO7983	COAD	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation rewiring degron network	0.0556
p.E426K	TCGA-DK-A3X1	BLCA	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation rewiring degron network	0.1389
p.E426K	DO447	BLCA	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation rewiring degron network	0.1389
p.A423T	TCGA-DU-6392	LGG	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation rewiring degron network	0.0556
p.A423T	DO22237	LGG	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation rewiring degron network	0.0556
p.N531D	TCGA-DX-AB2E	SARC	TCGA	DSDNSMSVPSP	DEG_COP1_1	528:538	Mutation altering degron motif	0.5821
p.N531D	DO220073	SARC	ICGC	DSDNSMSVPSP	DEG_COP1_1	528:538	Mutation altering degron motif	0.5821
p.S617Y	TCGA-EI-6917	READ	TCGA	VVSST	DEG_SPOP_SBC_1	615:619	Mutation altering degron motif	0.8231
p.S617Y	DO36881	READ	ICGC	VVSST	DEG_SPOP_SBC_1	615:619	Mutation altering degron motif	0.8231
p.S629L	TCGA-EK-A3GK	CESC	TCGA	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.0556
p.S629L	DO49964	CESC	ICGC	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.0556
p.P606T	TCGA-FD-A43P	BLCA	TCGA	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.0833
p.P606T	DO44049	BLCA	ICGC	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.0833
p.P428L	TCGA-SL-A6JA	UCEC	TCGA	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation rewiring degron network	0.1944
p.P428L	DO219787	UCEC	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation rewiring degron network	0.1944
p.D429N	DO234243	ESAD	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation rewiring degron network	0.2222
p.T542M	DO233102	GACA	ICGC	DSDNSMSVPSP	DEG_COP1_1	528:538	Mutation blocking phosphorylation signal	0.6667
p.R620H	DO233888	GACA	ICGC	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.3056
p.N548Y	DO228743	LICA	ICGC	DSDNSMSVPSP	DEG_COP1_1	528:538	Mutation rewiring degron network	0.0556
p.V622L	DO228976	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.25
p.M436I	DO229018	LICA	ICGC	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation altering degron motif	0.6507
p.V616F	DO229026	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	615:619	Mutation altering degron motif	0.5957
p.S540I	DO229037	LICA	ICGC	DSDNSMSVPSP	DEG_COP1_1	528:538	Mutation rewiring degron network	0.2778
p.R627I	DO229006	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1111
p.P498H	DO229213	THCA	ICGC	KRKQLHQLL	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.3056
p.Q503K	DO229248	THCA	ICGC	KRKQLHQLL	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.1667
p.R434S	SIDM00212	Glioblastoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation altering degron motif	0.6316
p.R434S	ACH-000464	Brain Cancer	CCLE	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation altering degron motif	0.6316
p.R434S	CAS-1	central nervous system	COSMIC	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation altering degron motif	0.6316
p.R620L	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.3056
p.R620L	ACH-000638	Lung Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.3056
p.R620L	NCI-H441	lung	COSMIC	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.3056
p.E432Q	SIDM00414	Bladder Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation rewiring degron network	0.3056
p.E432Q	ACH-000545	Bladder Cancer	CCLE	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation rewiring degron network	0.3056
p.E432Q	VM-CUB-1	urinary tract	COSMIC	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation rewiring degron network	0.3056
p.N531I	SIDM00940	Breast Carcinoma	GDSC	DSDNSMSVPSP	DEG_COP1_1	528:538	Mutation altering degron motif	0.6169
p.N531I	CAL-120	breast	COSMIC	DSDNSMSVPSP	DEG_COP1_1	528:538	Mutation altering degron motif	0.6169
p.D480Y	SIDM00217	Colorectal Carcinoma	GDSC	KRKQLHQLL	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.0833
p.D480Y	ACH-000999	Colon/Colorectal Cancer	CCLE	KRKQLHQLL	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.0833
p.D480Y	SNU-1040	large intestine	COSMIC	KRKQLHQLL	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.0833
p.H487Y	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRKQLHQLL	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.2778
p.H487Y	ACH-001638	Lymphoma	CCLE	KRKQLHQLL	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.2778
p.H487Y	RC-K8	haematopoietic and lymphoid tissue	COSMIC	KRKQLHQLL	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.2778
p.T435M	SIDM00980	Gastric Carcinoma	GDSC	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation altering degron motif	0.6312
p.T435M	ACH-000948	Gastric Cancer	CCLE	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation altering degron motif	0.6312
p.T435M	ACH-001622	Brain Cancer	CCLE	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation altering degron motif	0.6312
p.T435M	23132-87	stomach	COSMIC	FRTMWVIGL	DEG_MDM2_SWIB_1	433:441	Mutation altering degron motif	0.6312
p.R627G	SIDM01393	Gastric Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1111
p.R627G	ACH-000466	Gastric Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1111
p.T611M	ACH-002026	Endometrial/Uterine Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PAPOLA

UniProt ID: P51003

Entrez ID: 10914

Protein name: Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PAPOLA in