DegronMD

Uniprot ID: P51003

Source protein: Poly

Source gene: PAPOLA

Class: DEG_COP1_1

Location: 528:538

E3 ligase: COP1

DEGRON score: 0.9985

ASA_SCORE: 97.5364

COIL: 0.9449

CONS_SCORE: 0.2252

DSS_SCORE: 0.628

HELIX: 0.0448

FCONS_SCORE: 1.0338

RIG_SCORE: 0.604

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D524A	TCGA-39-5030	LUSC	TCGA	DSDNSMSVPSP	DEG_COP1_1	0.2222
p.D524A	DO27176	LUSC	ICGC	DSDNSMSVPSP	DEG_COP1_1	0.2222
p.D524N	TCGA-D1-A17Q	UCEC	TCGA	DSDNSMSVPSP	DEG_COP1_1	0.2222
p.D524N	TCGA-IB-7651	PAAD	TCGA	DSDNSMSVPSP	DEG_COP1_1	0.2222
p.D524N	DO46657	PAAD	ICGC	DSDNSMSVPSP	DEG_COP1_1	0.2222
p.D524N	DO41903	UCEC	ICGC	DSDNSMSVPSP	DEG_COP1_1	0.2222
p.N531D	TCGA-DX-AB2E	SARC	TCGA	DSDNSMSVPSP	DEG_COP1_1	0.5821
p.N531D	DO220073	SARC	ICGC	DSDNSMSVPSP	DEG_COP1_1	0.5821
p.T542M	DO233102	GACA	ICGC	DSDNSMSVPSP	DEG_COP1_1	0.6667
p.N548Y	DO228743	LICA	ICGC	DSDNSMSVPSP	DEG_COP1_1	0.0556
p.S540I	DO229037	LICA	ICGC	DSDNSMSVPSP	DEG_COP1_1	0.2778
p.N531I	SIDM00940	Breast Carcinoma	GDSC	DSDNSMSVPSP	DEG_COP1_1	0.6169
p.N531I	CAL-120	breast	COSMIC	DSDNSMSVPSP	DEG_COP1_1	0.6169

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51003	Poly	DEG_COP1_1	528:538	DSDNSMSVPSP	COP1	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons