DegronMD

Uniprot ID: P51003

Source protein: Poly

Source gene: PAPOLA

Class: DEG_APCC_DBOX_1

Location: 489:497

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9608

ASA_SCORE: 75.8556

COIL: 0.3153

CONS_SCORE: 0.3702

DSS_SCORE: 0.3763

HELIX: 0.623

FCONS_SCORE: 1.3443

RIG_SCORE: 0.7872

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P498H	DO229213	THCA	ICGC	KRKQLHQLL	DEG_APCC_DBOX_1	0.3056
p.Q503K	DO229248	THCA	ICGC	KRKQLHQLL	DEG_APCC_DBOX_1	0.1667
p.D480Y	SIDM00217	Colorectal Carcinoma	GDSC	KRKQLHQLL	DEG_APCC_DBOX_1	0.0833
p.D480Y	ACH-000999	Colon/Colorectal Cancer	CCLE	KRKQLHQLL	DEG_APCC_DBOX_1	0.0833
p.D480Y	SNU-1040	large_intestine	COSMIC	KRKQLHQLL	DEG_APCC_DBOX_1	0.0833
p.H487Y	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRKQLHQLL	DEG_APCC_DBOX_1	0.2778
p.H487Y	ACH-001638	Lymphoma	CCLE	KRKQLHQLL	DEG_APCC_DBOX_1	0.2778
p.H487Y	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	KRKQLHQLL	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51003	Poly	DEG_APCC_DBOX_1	489:497	KRKQLHQLL	APC,CDC20,FZR1	0.9608	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons