DegronMD

Uniprot ID: P16144

Source protein: Integrin beta-4

Source gene: ITGB4

Class: DEG_SPOP_SBC_1

Location: 1230:1234

E3 ligase: SPOP

DEGRON score: 0.5329

ASA_SCORE: 62.68

COIL: 0.5704

CONS_SCORE: 0.706

DSS_SCORE: 0.2774

HELIX: 0.0036

FCONS_SCORE: 0.9536

RIG_SCORE: 0.8105

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1221R	TCGA-43-6143	LUSC	TCGA	VVSST	DEG_SPOP_SBC_1	0.0833
p.S1221R	DO26428	LUSC	ICGC	VVSST	DEG_SPOP_SBC_1	0.0833
p.R1225C	TCGA-85-8664	LUSC	TCGA	VVSST	DEG_SPOP_SBC_1	0.1944
p.R1225C	DO45469	LUSC	ICGC	VVSST	DEG_SPOP_SBC_1	0.1944
p.V1231I	DO233888	GACA	ICGC	VVSST	DEG_SPOP_SBC_1	0.5965
p.V1231I	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	0.5965
p.V1231I	ACH-000669	Lung Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.5965
p.V1231I	SW900	lung	COSMIC	VVSST	DEG_SPOP_SBC_1	0.5965
p.N1229D	SIDM00615	Hepatocellular Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	0.3056
p.N1229D	SIDM00526	Chronic Myelogenous Leukemia	GDSC	VVSST	DEG_SPOP_SBC_1	0.3056
p.N1229D	SIDM01573	Plasma Cell Myeloma	GDSC	VVSST	DEG_SPOP_SBC_1	0.3056
p.N1229D	JHH-6	liver	COSMIC	VVSST	DEG_SPOP_SBC_1	0.3056
p.N1229D	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	0.3056
p.T1234M	SIDM00217	Colorectal Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	0.7423
p.T1234M	ACH-000999	Colon/Colorectal Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.7423
p.T1234M	SNU-1040	large_intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	0.7423
p.S1221N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VVSST	DEG_SPOP_SBC_1	0.0833
p.S1221N	ACH-002222	Leukemia	CCLE	VVSST	DEG_SPOP_SBC_1	0.0833
p.S1221N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	184:188	VVSST	SPOP	0.9948	More...
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1230:1234	VVSST	SPOP	0.5329	More...
P21583	Kit ligand	DEG_SPOP_SBC_1	164:168	VVSST	SPOP	0.9767	More...
P51003	Poly	DEG_SPOP_SBC_1	615:619	VVSST	SPOP	0.7739	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1337:1341	VVSST	SPOP	0.7602	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1739:1743	VVSST	SPOP	0.9233	More...
Q14241	Elongin-A	DEG_SPOP_SBC_1	763:767	VVSST	SPOP	0.7077	More...
Q8N573	Oxidation resistance protein 1	DEG_SPOP_SBC_1	199:203	VVSST	SPOP	0.9992	More...
Q96B97	SH3 domain-containing kinase-binding protein 1	DEG_SPOP_SBC_1	469:473	VVSST	SPOP	0.9973	More...
Q9BXR0	Queuine tRNA-ribosyltransferase catalytic subunit 1	DEG_SPOP_SBC_1	161:165	VVSST	SPOP	0.5555	More...
Q9HCP0	Casein kinase I isoform gamma-1	DEG_SPOP_SBC_1	370:374	VVSST	SPOP	0.9967	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	337:341	VVSST	SPOP	0.9646	More...
Q9Y6M4	Casein kinase I isoform gamma-3	DEG_SPOP_SBC_1	395:399	VVSST	SPOP	0.9966	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	614:618	VVSST	SPOP	0.8298	More...
Q8NEM2	SHC SH2 domain-binding protein 1	DEG_SPOP_SBC_1	334:338	VVSST	SPOP	0.5138	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons