DegronMD

Uniprot ID: Q96B97

Source protein: SH3 domain-containing kinase-binding protein 1

Source gene: SH3KBP1

Class: DEG_SPOP_SBC_1

Location: 469:473

E3 ligase: SPOP

DEGRON score: 0.9973

ASA_SCORE: 70.76

COIL: 0.7318

CONS_SCORE: 0.3958

DSS_SCORE: 0.4972

HELIX: 0.0902

FCONS_SCORE: 1.0872

RIG_SCORE: 0.6781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V469M	TCGA-EA-A3HQ	CESC	TCGA	VVSST	DEG_SPOP_SBC_1	0.7208
p.T473A	TCGA-F5-6814	READ	TCGA	VVSST	DEG_SPOP_SBC_1	0.825
p.T473A	DO36556	READ	ICGC	VVSST	DEG_SPOP_SBC_1	0.825
p.D460N	TCGA-GC-A6I1	BLCA	TCGA	VVSST	DEG_SPOP_SBC_1	0.0833
p.D460N	DO49770	BLCA	ICGC	VVSST	DEG_SPOP_SBC_1	0.0833
p.L473P	DO7855	COAD	ICGC	VVSST	DEG_SPOP_SBC_1	0.7582
p.A481V	DO233267	GACA	ICGC	VVSST	DEG_SPOP_SBC_1	0.1111
p.P479L	DO233867	GACA	ICGC	VVSST	DEG_SPOP_SBC_1	0.1667
p.T480N	DO49665	LIAD	ICGC	VVSST	DEG_SPOP_SBC_1	0.1389
p.S482R	DO229019	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.0833
p.S482R	DO229008	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.0833
p.P463S	DO222749	MELA	ICGC	VVSST	DEG_SPOP_SBC_1	0.1667
p.S482T	DO229259	THCA	ICGC	VVSST	DEG_SPOP_SBC_1	0.0833
p.E464D	SIDM00528	Breast Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	0.1944
p.E464D	ACH-000934	Breast Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.1944
p.E464D	MDA-MB-361	breast	COSMIC	VVSST	DEG_SPOP_SBC_1	0.1944
p.S471L	ACH-000490	Cervical Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.7667
p.P469L	SNU-1040	large_intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	184:188	VVSST	SPOP	0.9948	More...
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1230:1234	VVSST	SPOP	0.5329	More...
P21583	Kit ligand	DEG_SPOP_SBC_1	164:168	VVSST	SPOP	0.9767	More...
P51003	Poly	DEG_SPOP_SBC_1	615:619	VVSST	SPOP	0.7739	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1337:1341	VVSST	SPOP	0.7602	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1739:1743	VVSST	SPOP	0.9233	More...
Q14241	Elongin-A	DEG_SPOP_SBC_1	763:767	VVSST	SPOP	0.7077	More...
Q8N573	Oxidation resistance protein 1	DEG_SPOP_SBC_1	199:203	VVSST	SPOP	0.9992	More...
Q96B97	SH3 domain-containing kinase-binding protein 1	DEG_SPOP_SBC_1	469:473	VVSST	SPOP	0.9973	More...
Q9BXR0	Queuine tRNA-ribosyltransferase catalytic subunit 1	DEG_SPOP_SBC_1	161:165	VVSST	SPOP	0.5555	More...
Q9HCP0	Casein kinase I isoform gamma-1	DEG_SPOP_SBC_1	370:374	VVSST	SPOP	0.9967	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	337:341	VVSST	SPOP	0.9646	More...
Q9Y6M4	Casein kinase I isoform gamma-3	DEG_SPOP_SBC_1	395:399	VVSST	SPOP	0.9966	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	614:618	VVSST	SPOP	0.8298	More...
Q8NEM2	SHC SH2 domain-binding protein 1	DEG_SPOP_SBC_1	334:338	VVSST	SPOP	0.5138	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons