DegronMD - Q8N573(OXR1)

FUNCTION: May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}.

GO - Biological processes (BP): adult walking behavior [GO:0007628]; cellular response to hydroperoxide [GO:0071447]; negative regulation of cellular response to oxidative stress [GO:1900408]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced neuron death [GO:1903204]; ne... View more >>

GO - Molecular function (MF): oxidoreductase activity [GO:0016491]

GO - Cellular component (CC): mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
DTGEYTREP	CBL_PTK	CBL	Oxidation resistance protein 1	618:626	More..
VVSST	DEG_SPOP_SBC_1	SPOP	Oxidation resistance protein 1	199:203	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S201F	GP5d	large intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.9093
p.S203F	DO225382	BRCA	ICGC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.7982
p.S200F	GP5d	large intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.7982
p.E204D	ACH-000991	Colon/Colorectal Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	199:203	Mutation blocking phosphorylation signal	0.75
p.E204D	SNU-81	large intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation blocking phosphorylation signal	0.75
p.D204Y	NCI-H510A	lung	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation blocking phosphorylation signal	0.75
p.I626F	ACH-000453	Myeloma	CCLE	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.7415
p.I626F	ACH-000620	Liver Cancer	CCLE	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.7415
p.I626F	JHH-1	liver	COSMIC	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.7415
p.K625T	ACH-000991	Colon/Colorectal Cancer	CCLE	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.7306
p.K625T	SNU-81	large intestine	COSMIC	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.7306
p.G619D	DO1285	BRCA	ICGC	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.7198
p.E620K	DO42793	UCEC	ICGC	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.7022
p.E620K	DO42713	UCEC	ICGC	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.7022
p.K201N	DO49876	LUAD	ICGC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.6918
p.V199L	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.6765
p.G620D	TCGA-AN-A046	BRCA	TCGA	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.6087
p.E621K	TCGA-BS-A0UV	UCEC	TCGA	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.591
p.E621K	TCGA-EO-A22R	UCEC	TCGA	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.591
p.V192L	ACH-000112	Leukemia	CCLE	VVSST	DEG_SPOP_SBC_1	199:203	Mutation blocking phosphorylation signal	0.5833

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Kaplan plot for OXR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OXR1

UniProt ID: Q8N573

Entrez ID: 55074

Protein name: Oxidation resistance protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OXR1 in