DegronMD - Q8N573(OXR1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R198Q	TCGA-3A-A9IZ	PAAD	TCGA	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.3056
p.R195Q	TCGA-AA-3864	COAD	TCGA	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2222
p.R195Q	TCGA-AO-A128	BRCA	TCGA	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2222
p.R195Q	TCGA-ND-A4WC	UCS	TCGA	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2222
p.G620D	TCGA-AN-A046	BRCA	TCGA	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.6087
p.E621K	TCGA-BS-A0UV	UCEC	TCGA	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.591
p.E621K	TCGA-EO-A22R	UCEC	TCGA	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.591
p.E212D	TCGA-EO-A3AY	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0833
p.E212D	SIDM00193	Colorectal Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0833
p.E212D	SNU-81	large intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0833
p.S203F	DO225382	BRCA	ICGC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.7982
p.F190L	DO1158	BRCA	ICGC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation blocking phosphorylation signal	0.5278
p.G619D	DO1285	BRCA	ICGC	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.7198
p.R194Q	DO5326	BRCA	ICGC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1944
p.R194Q	DO8490	COAD	ICGC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1944
p.P611L	DO52451	COCA	ICGC	DTGEYTREP	CBL_PTK	618:626	Mutation rewiring degron network	0.1389
p.R197Q	DO233705	GACA	ICGC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2778
p.R197Q	DO218961	PAAD	ICGC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2778
p.S636Y	DO10880	GBM	ICGC	DTGEYTREP	CBL_PTK	618:626	Mutation rewiring degron network	0.0556
p.K632N	DO228194	LICA	ICGC	DTGEYTREP	CBL_PTK	618:626	Mutation substituting flanking lysine	0.2778
p.R197L	DO229028	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2778
p.K201N	DO49876	LUAD	ICGC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.6918
p.A196T	DO46372	OV	ICGC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.25
p.T210P	DO232761	PBCA	ICGC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1389
p.F213I	DO37434	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation blocking ubiquitination signal	0.5
p.E211D	DO43202	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation blocking phosphorylation signal	0.5556
p.E211D	SNU-81	large intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation blocking phosphorylation signal	0.5556
p.E620K	DO42793	UCEC	ICGC	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.7022
p.E620K	DO42713	UCEC	ICGC	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.7022
p.V200L	SIDM00396	Acute Myeloid Leukemia	GDSC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.5654
p.V200L	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.5654
p.K633T	SIDM00193	Colorectal Carcinoma	GDSC	DTGEYTREP	CBL_PTK	618:626	Mutation substituting flanking lysine	0.25
p.K633T	SNU-81	large intestine	COSMIC	DTGEYTREP	CBL_PTK	618:626	Mutation substituting flanking lysine	0.25
p.E613G	SIDM00878	Breast Carcinoma	GDSC	DTGEYTREP	CBL_PTK	618:626	Mutation rewiring degron network	0.1944
p.E613G	HCC1569	breast	COSMIC	DTGEYTREP	CBL_PTK	618:626	Mutation rewiring degron network	0.1944
p.I634F	SIDM00618	Hepatocellular Carcinoma	GDSC	DTGEYTREP	CBL_PTK	618:626	Mutation rewiring degron network	0.1111
p.I634F	SIDM01690	Plasma Cell Myeloma	GDSC	DTGEYTREP	CBL_PTK	618:626	Mutation rewiring degron network	0.1111
p.I634F	JHH-1	liver	COSMIC	DTGEYTREP	CBL_PTK	618:626	Mutation rewiring degron network	0.1111
p.F206L	ACH-000058	Thyroid Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.25
p.F206L	ACH-000990	Endometrial/Uterine Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.25
p.F206L	ML-1	thyroid	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.25
p.V192L	ACH-000112	Leukemia	CCLE	VVSST	DEG_SPOP_SBC_1	199:203	Mutation blocking phosphorylation signal	0.5833
p.V192L	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation blocking phosphorylation signal	0.5833
p.I626F	ACH-000453	Myeloma	CCLE	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.7415
p.I626F	ACH-000620	Liver Cancer	CCLE	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.7415
p.I626F	JHH-1	liver	COSMIC	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.7415
p.F206Y	ACH-000899	Skin Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.25
p.F210L	ACH-000976	Bile Duct Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1389
p.S193F	ACH-000982	Colon/Colorectal Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1667
p.S193F	ACH-001345	Colon/Colorectal Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1667
p.S193F	GP5d	large intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1667
p.E204D	ACH-000991	Colon/Colorectal Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	199:203	Mutation blocking phosphorylation signal	0.75
p.E204D	SNU-81	large intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation blocking phosphorylation signal	0.75
p.K625T	ACH-000991	Colon/Colorectal Cancer	CCLE	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.7306
p.K625T	SNU-81	large intestine	COSMIC	DTGEYTREP	CBL_PTK	618:626	Mutation altering degron motif	0.7306
p.E612G	HCC1569	breast	COSMIC	DTGEYTREP	CBL_PTK	618:626	Mutation rewiring degron network	0.1667
p.D204Y	NCI-H510A	lung	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation blocking phosphorylation signal	0.75
p.R197C	RL95-2	endometrium	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2778
p.V199L	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.6765
p.I633F	JHH-1	liver	COSMIC	DTGEYTREP	CBL_PTK	618:626	Mutation substituting flanking lysine	0.25
p.S200F	GP5d	large intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.7982
p.K632T	SNU-81	large intestine	COSMIC	DTGEYTREP	CBL_PTK	618:626	Mutation substituting flanking lysine	0.2778
p.S201F	GP5d	large intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.9093
p.F213L	ML-1	thyroid	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation blocking ubiquitination signal	0.5
p.G208R	NCI-H650	lung	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1944
p.G192A	NCI-H1355	lung	COSMIC	VVSST	DEG_SPOP_SBC_1	199:203	Mutation blocking phosphorylation signal	0.5833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OXR1

UniProt ID: Q8N573

Entrez ID: 55074

Protein name: Oxidation resistance protein 1

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for OXR1 in