DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DTGEYTREP
Uniprot ID:
Q8N573
Source protein:
Oxidation resistance protein 1
Source gene:
OXR1
Class:
CBL_PTK
Location:
618:626
E3 ligase:
CBL
DEGRON score:
0.5901
ASA_SCORE:
80.1889
COIL:
0.7611
CONS_SCORE:
0.3342
DSS_SCORE:
0.3142
HELIX:
0.15
FCONS_SCORE:
0.9303
RIG_SCORE:
0.7915
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G620D
TCGA-AN-A046
BRCA
TCGA
DTGEYTREP
CBL_PTK
0.6087
p.E621K
TCGA-BS-A0UV
UCEC
TCGA
DTGEYTREP
CBL_PTK
0.591
p.E621K
TCGA-EO-A22R
UCEC
TCGA
DTGEYTREP
CBL_PTK
0.591
p.G619D
DO1285
BRCA
ICGC
DTGEYTREP
CBL_PTK
0.7198
p.P611L
DO52451
COCA
ICGC
DTGEYTREP
CBL_PTK
0.1389
p.S636Y
DO10880
GBM
ICGC
DTGEYTREP
CBL_PTK
0.0556
p.K632N
DO228194
LICA
ICGC
DTGEYTREP
CBL_PTK
0.2778
p.E620K
DO42793
UCEC
ICGC
DTGEYTREP
CBL_PTK
0.7022
p.E620K
DO42713
UCEC
ICGC
DTGEYTREP
CBL_PTK
0.7022
p.K633T
SIDM00193
Colorectal Carcinoma
GDSC
DTGEYTREP
CBL_PTK
0.25
p.K633T
SNU-81
large_intestine
COSMIC
DTGEYTREP
CBL_PTK
0.25
p.E613G
SIDM00878
Breast Carcinoma
GDSC
DTGEYTREP
CBL_PTK
0.1944
p.E613G
HCC1569
breast
COSMIC
DTGEYTREP
CBL_PTK
0.1944
p.I634F
SIDM00618
Hepatocellular Carcinoma
GDSC
DTGEYTREP
CBL_PTK
0.1111
p.I634F
SIDM01690
Plasma Cell Myeloma
GDSC
DTGEYTREP
CBL_PTK
0.1111
p.I634F
JHH-1
liver
COSMIC
DTGEYTREP
CBL_PTK
0.1111
p.I626F
ACH-000453
Myeloma
CCLE
DTGEYTREP
CBL_PTK
0.7415
p.I626F
ACH-000620
Liver Cancer
CCLE
DTGEYTREP
CBL_PTK
0.7415
p.I626F
JHH-1
liver
COSMIC
DTGEYTREP
CBL_PTK
0.7415
p.K625T
ACH-000991
Colon/Colorectal Cancer
CCLE
DTGEYTREP
CBL_PTK
0.7306
p.K625T
SNU-81
large_intestine
COSMIC
DTGEYTREP
CBL_PTK
0.7306
p.E612G
HCC1569
breast
COSMIC
DTGEYTREP
CBL_PTK
0.1667
p.I633F
JHH-1
liver
COSMIC
DTGEYTREP
CBL_PTK
0.25
p.K632T
SNU-81
large_intestine
COSMIC
DTGEYTREP
CBL_PTK
0.2778
Drug responses associated with OXR1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DTGEYTREP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N573
Oxidation resistance protein 1
CBL_PTK
618:626
DTGEYTREP
CBL
0.5901
More...