DegronMD

Uniprot ID: Q8N573

Source protein: Oxidation resistance protein 1

Source gene: OXR1

Class: DEG_SPOP_SBC_1

Location: 199:203

E3 ligase: SPOP

DEGRON score: 0.9992

ASA_SCORE: 76.84

COIL: 0.8934

CONS_SCORE: 0.3464

DSS_SCORE: 0.4727

HELIX: 0.047

FCONS_SCORE: 1.0551

RIG_SCORE: 0.7356

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R198Q	TCGA-3A-A9IZ	PAAD	TCGA	VVSST	DEG_SPOP_SBC_1	0.3056
p.R195Q	TCGA-AA-3864	COAD	TCGA	VVSST	DEG_SPOP_SBC_1	0.2222
p.R195Q	TCGA-AO-A128	BRCA	TCGA	VVSST	DEG_SPOP_SBC_1	0.2222
p.R195Q	TCGA-ND-A4WC	UCS	TCGA	VVSST	DEG_SPOP_SBC_1	0.2222
p.E212D	TCGA-EO-A3AY	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	0.0833
p.E212D	SIDM00193	Colorectal Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	0.0833
p.E212D	SNU-81	large_intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	0.0833
p.S203F	DO225382	BRCA	ICGC	VVSST	DEG_SPOP_SBC_1	0.7982
p.F190L	DO1158	BRCA	ICGC	VVSST	DEG_SPOP_SBC_1	0.5278
p.R194Q	DO5326	BRCA	ICGC	VVSST	DEG_SPOP_SBC_1	0.1944
p.R194Q	DO8490	COAD	ICGC	VVSST	DEG_SPOP_SBC_1	0.1944
p.R197Q	DO233705	GACA	ICGC	VVSST	DEG_SPOP_SBC_1	0.2778
p.R197Q	DO218961	PAAD	ICGC	VVSST	DEG_SPOP_SBC_1	0.2778
p.R197L	DO229028	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	0.2778
p.K201N	DO49876	LUAD	ICGC	VVSST	DEG_SPOP_SBC_1	0.6918
p.A196T	DO46372	OV	ICGC	VVSST	DEG_SPOP_SBC_1	0.25
p.T210P	DO232761	PBCA	ICGC	VVSST	DEG_SPOP_SBC_1	0.1389
p.F213I	DO37434	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	0.5
p.E211D	DO43202	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	0.5556
p.E211D	SNU-81	large_intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	0.5556
p.V200L	SIDM00396	Acute Myeloid Leukemia	GDSC	VVSST	DEG_SPOP_SBC_1	0.5654
p.V200L	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	0.5654
p.F206L	ACH-000058	Thyroid Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.25
p.F206L	ACH-000990	Endometrial/Uterine Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.25
p.F206L	ML-1	thyroid	COSMIC	VVSST	DEG_SPOP_SBC_1	0.25
p.V192L	ACH-000112	Leukemia	CCLE	VVSST	DEG_SPOP_SBC_1	0.5833
p.V192L	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	0.5833
p.F206Y	ACH-000899	Skin Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.25
p.F210L	ACH-000976	Bile Duct Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.1389
p.S193F	ACH-000982	Colon/Colorectal Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.1667
p.S193F	ACH-001345	Colon/Colorectal Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.1667
p.S193F	GP5d	large_intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	0.1667
p.E204D	ACH-000991	Colon/Colorectal Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.75
p.E204D	SNU-81	large_intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	0.75
p.D204Y	NCI-H510A	lung	COSMIC	VVSST	DEG_SPOP_SBC_1	0.75
p.R197C	RL95-2	endometrium	COSMIC	VVSST	DEG_SPOP_SBC_1	0.2778
p.V199L	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	0.6765
p.S200F	GP5d	large_intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	0.7982
p.S201F	GP5d	large_intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	0.9093
p.F213L	ML-1	thyroid	COSMIC	VVSST	DEG_SPOP_SBC_1	0.5
p.G208R	NCI-H650	lung	COSMIC	VVSST	DEG_SPOP_SBC_1	0.1944
p.G192A	NCI-H1355	lung	COSMIC	VVSST	DEG_SPOP_SBC_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	184:188	VVSST	SPOP	0.9948	More...
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1230:1234	VVSST	SPOP	0.5329	More...
P21583	Kit ligand	DEG_SPOP_SBC_1	164:168	VVSST	SPOP	0.9767	More...
P51003	Poly	DEG_SPOP_SBC_1	615:619	VVSST	SPOP	0.7739	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1337:1341	VVSST	SPOP	0.7602	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1739:1743	VVSST	SPOP	0.9233	More...
Q14241	Elongin-A	DEG_SPOP_SBC_1	763:767	VVSST	SPOP	0.7077	More...
Q8N573	Oxidation resistance protein 1	DEG_SPOP_SBC_1	199:203	VVSST	SPOP	0.9992	More...
Q96B97	SH3 domain-containing kinase-binding protein 1	DEG_SPOP_SBC_1	469:473	VVSST	SPOP	0.9973	More...
Q9BXR0	Queuine tRNA-ribosyltransferase catalytic subunit 1	DEG_SPOP_SBC_1	161:165	VVSST	SPOP	0.5555	More...
Q9HCP0	Casein kinase I isoform gamma-1	DEG_SPOP_SBC_1	370:374	VVSST	SPOP	0.9967	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	337:341	VVSST	SPOP	0.9646	More...
Q9Y6M4	Casein kinase I isoform gamma-3	DEG_SPOP_SBC_1	395:399	VVSST	SPOP	0.9966	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	614:618	VVSST	SPOP	0.8298	More...
Q8NEM2	SHC SH2 domain-binding protein 1	DEG_SPOP_SBC_1	334:338	VVSST	SPOP	0.5138	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVSST

Degron related mutations and impact score

Drug responses associated with OXR1 mutations

All proteins holding degron of VVSST