DegronMD - Q8NEM2(SHCBP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R325H	TCGA-AD-6964	COAD	TCGA	VVSST	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0833
p.R325H	TCGA-D7-A6EY	STAD	TCGA	VVSST	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0833
p.R325H	DO8360	COAD	ICGC	VVSST	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0833
p.R325H	DO50118	STAD	ICGC	VVSST	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0833
p.N539H	TCGA-BH-A0HQ	BRCA	TCGA	KPTIFSD	LIG_APCC_ABBAyCdc20_2	548:554	Mutation rewiring degron network	0.0833
p.N539H	DO3082	BRCA	ICGC	KPTIFSD	LIG_APCC_ABBAyCdc20_2	548:554	Mutation rewiring degron network	0.0833
p.R325C	TCGA-D1-A17H	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0833
p.R325C	DO41847	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0833
p.R345Q	TCGA-EA-A410	CESC	TCGA	VVSST	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.R345Q	DO49929	CESC	ICGC	VVSST	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.R345Q	SIDM01154	T-Lymphoblastic Leukemia	GDSC	VVSST	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.A559G	TCGA-MI-A75E	LIHC	TCGA	KPTIFSD	LIG_APCC_ABBAyCdc20_2	548:554	Mutation rewiring degron network	0.1944
p.A559G	DO49707	LIHC	ICGC	KPTIFSD	LIG_APCC_ABBAyCdc20_2	548:554	Mutation rewiring degron network	0.1944
p.G562E	DO222884	COCA	ICGC	KPTIFSD	LIG_APCC_ABBAyCdc20_2	548:554	Mutation rewiring degron network	0.1111
p.T563N	DO229036	LICA	ICGC	KPTIFSD	LIG_APCC_ABBAyCdc20_2	548:554	Mutation rewiring degron network	0.0833
p.P549L	SIDM00473	Oral Cavity Carcinoma	GDSC	KPTIFSD	LIG_APCC_ABBAyCdc20_2	548:554	Mutation altering degron motif	0.6471
p.P549L	ACH-000619	Head and Neck Cancer	CCLE	KPTIFSD	LIG_APCC_ABBAyCdc20_2	548:554	Mutation altering degron motif	0.6471
p.G541S	SIDM01412	Oral Cavity Carcinoma	GDSC	KPTIFSD	LIG_APCC_ABBAyCdc20_2	548:554	Mutation rewiring degron network	0.1389
p.G541S	ACH-000762	Head and Neck Cancer	CCLE	KPTIFSD	LIG_APCC_ABBAyCdc20_2	548:554	Mutation rewiring degron network	0.1389
p.G543V	SIDM01387	Small Cell Lung Carcinoma	GDSC	KPTIFSD	LIG_APCC_ABBAyCdc20_2	548:554	Mutation rewiring degron network	0.1944
p.G543V	ACH-000921	Lung Cancer	CCLE	KPTIFSD	LIG_APCC_ABBAyCdc20_2	548:554	Mutation rewiring degron network	0.1944

Kaplan plot for SHCBP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHCBP1

UniProt ID: Q8NEM2

Entrez ID: 79801

Protein name: SHC SH2 domain-binding protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHCBP1 in