DegronMD

Uniprot ID: Q8NEM2

Source protein: SHC SH2 domain-binding protein 1

Source gene: SHCBP1

Class: LIG_APCC_ABBAyCdc20_2

Location: 548:554

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8346

ASA_SCORE: 49.2143

COIL: 0.7551

CONS_SCORE: 0.2731

DSS_SCORE: 0.3039

HELIX: 0.0936

FCONS_SCORE: 0.7425

RIG_SCORE: 0.854

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N539H	TCGA-BH-A0HQ	BRCA	TCGA	KPTIFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.N539H	DO3082	BRCA	ICGC	KPTIFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.A559G	TCGA-MI-A75E	LIHC	TCGA	KPTIFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.A559G	DO49707	LIHC	ICGC	KPTIFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.G562E	DO222884	COCA	ICGC	KPTIFSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T563N	DO229036	LICA	ICGC	KPTIFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.P549L	SIDM00473	Oral Cavity Carcinoma	GDSC	KPTIFSD	LIG_APCC_ABBAyCdc20_2	0.6471
p.P549L	ACH-000619	Head and Neck Cancer	CCLE	KPTIFSD	LIG_APCC_ABBAyCdc20_2	0.6471
p.G541S	SIDM01412	Oral Cavity Carcinoma	GDSC	KPTIFSD	LIG_APCC_ABBAyCdc20_2	0.1389
p.G541S	ACH-000762	Head and Neck Cancer	CCLE	KPTIFSD	LIG_APCC_ABBAyCdc20_2	0.1389
p.G543V	SIDM01387	Small Cell Lung Carcinoma	GDSC	KPTIFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.G543V	ACH-000921	Lung Cancer	CCLE	KPTIFSD	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEM2	SHC SH2 domain-binding protein 1	LIG_APCC_ABBAyCdc20_2	548:554	KPTIFSD	APC,CDC20,FZR1	0.8346	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons