DegronMD - Q96B97(SH3KBP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G582A	TCGA-55-6712	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1944
p.A569V	TCGA-BS-A0TA	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.2222
p.A569V	TCGA-D8-A1XR	BRCA	TCGA	PLSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.2222
p.S577P	TCGA-CG-4477	STAD	TCGA	PLSSS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.7863
p.V469M	TCGA-EA-A3HQ	CESC	TCGA	VVSST	DEG_SPOP_SBC_1	469:473	Mutation altering degron motif	0.7208
p.T473A	TCGA-F5-6814	READ	TCGA	VVSST	DEG_SPOP_SBC_1	469:473	Mutation altering degron motif	0.825
p.T473A	DO36556	READ	ICGC	VVSST	DEG_SPOP_SBC_1	469:473	Mutation altering degron motif	0.825
p.P571L	TCGA-FR-A726	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.2778
p.P571L	DO48665	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.2778
p.D460N	TCGA-GC-A6I1	BLCA	TCGA	VVSST	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.0833
p.D460N	DO49770	BLCA	ICGC	VVSST	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.0833
p.L473P	DO7855	COAD	ICGC	VVSST	DEG_SPOP_SBC_1	469:473	Mutation altering degron motif	0.7582
p.A481V	DO233267	GACA	ICGC	VVSST	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1111
p.A564D	DO233738	GACA	ICGC	PLSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.0833
p.P479L	DO233867	GACA	ICGC	VVSST	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1667
p.T480N	DO49665	LIAD	ICGC	VVSST	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1389
p.S482R	DO229019	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.0833
p.S482R	DO229008	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.0833
p.P463S	DO222749	MELA	ICGC	VVSST	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1667
p.S482T	DO229259	THCA	ICGC	VVSST	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.0833
p.E587K	DO50076	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	573:577	Mutation blocking phosphorylation signal	0.5
p.H583Q	SIDM00845	Burkitt's Lymphoma	GDSC	PLSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1667
p.A570V	SIDM01113	Other Sarcomas	GDSC	PLSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.25
p.A570V	ACH-000939	Sarcoma	CCLE	PLSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.25
p.A570V	SK-UT-1	soft tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.25
p.E464D	SIDM00528	Breast Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1944
p.E464D	ACH-000934	Breast Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1944
p.E464D	MDA-MB-361	breast	COSMIC	VVSST	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1944
p.S567T	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1667
p.S471L	ACH-000490	Cervical Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	469:473	Mutation altering degron motif	0.7667
p.P469L	SNU-1040	large intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	469:473	Mutation altering degron motif	0.7582
p.A565V	SNU-C5	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1111

Kaplan plot for SH3KBP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH3KBP1

UniProt ID: Q96B97

Entrez ID: 30011

Protein name: SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH3KBP1 in