DegronMD

Uniprot ID: Q96B97

Source protein: SH3 domain-containing kinase-binding protein 1

Source gene: SH3KBP1

Class: DEG_SPOP_SBC_1

Location: 573:577

E3 ligase: SPOP

DEGRON score: 0.9968

ASA_SCORE: 85.18

COIL: 0.9304

CONS_SCORE: 0.4177

DSS_SCORE: 0.6139

HELIX: 0.045

FCONS_SCORE: 1.0502

RIG_SCORE: 0.5665

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S577P	TCGA-CG-4477	STAD	TCGA	PLSSS	DEG_SPOP_SBC_1	0.7863
p.E587K	DO50076	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	0.5
p.P571L	TCGA-FR-A726	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	0.2778
p.P571L	DO48665	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	0.2778
p.A570V	SIDM01113	Other Sarcomas	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A570V	ACH-000939	Sarcoma	CCLE	PLSSS	DEG_SPOP_SBC_1	0.25
p.A570V	SK-UT-1	soft_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A569V	TCGA-BS-A0TA	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	0.2222
p.A569V	TCGA-D8-A1XR	BRCA	TCGA	PLSSS	DEG_SPOP_SBC_1	0.2222
p.G582A	TCGA-55-6712	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	0.1944
p.H583Q	SIDM00845	Burkitt's Lymphoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.S567T	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.A565V	SNU-C5	large_intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1111
p.A564D	DO233738	GACA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 14 of 14 entries

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Drug responses associated with SH3KBP1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PLSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60825	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2	DEG_SPOP_SBC_1	469:473	PLSSS	SPOP	0.9968	More...
O00763	Acetyl-CoA carboxylase 2	DEG_SPOP_SBC_1	103:107	PLSSS	SPOP	0.9873	More...
Q8IZF5	Adhesion G-protein coupled receptor F3	DEG_SPOP_SBC_1	69:73	PLSSS	SPOP	0.8794	More...
Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	478:482	PLSSS	SPOP	0.779	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	1226:1230	PLSSS	SPOP	0.982	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	77:81	PLSSS	SPOP	0.9962	More...
P04637	Cellular tumor antigen p53	DEG_SPOP_SBC_1	92:96	PLSSS	SPOP	0.9977	More...
Q8N684	Cleavage and polyadenylation specificity factor subunit 7	DEG_SPOP_SBC_1	247:251	PLSSS	SPOP	0.9926	More...
Q9P218	Collagen alpha-1	DEG_SPOP_SBC_1	615:619	PLSSS	SPOP	0.9976	More...
Q9NS37	CREB/ATF bZIP transcription factor	DEG_SPOP_SBC_1	129:133	PLSSS	SPOP	0.9398	More...
Q9P2B4	CTTNBP2 N-terminal-like protein	DEG_SPOP_SBC_1	405:409	PLSSS	SPOP	0.9931	More...
Q2TBE0	CWF19-like protein 2	DEG_SPOP_SBC_1	388:392	PLSSS	SPOP	0.9997	More...
Q9Y4D2	Diacylglycerol lipase-alpha	DEG_SPOP_SBC_1	993:997	PLSSS	SPOP	0.7658	More...
P11388	DNA topoisomerase 2-alpha	DEG_SPOP_SBC_1	1389:1393	PLSSS	SPOP	0.9972	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1507:1511	PLSSS	SPOP	0.9967	More...
O75140	GATOR complex protein DEPDC5	DEG_SPOP_SBC_1	829:833	PLSSS	SPOP	0.9934	More...
Q9ULK0	Glutamate receptor ionotropic, delta-1	DEG_SPOP_SBC_1	954:958	PLSSS	SPOP	0.9853	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	288:292	PLSSS	SPOP	0.9368	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1434:1438	PLSSS	SPOP	0.9226	More...
Q9UBC0	Hepatocyte nuclear factor 6	DEG_SPOP_SBC_1	181:185	PLSSS	SPOP	0.5617	More...
Q92993	Histone acetyltransferase KAT5	DEG_SPOP_SBC_1	133:137	PLSSS	SPOP	0.9685	More...
Q9UIU6	Homeobox protein SIX4	DEG_SPOP_SBC_1	311:315	PLSSS	SPOP	0.9014	More...
P14316	Interferon regulatory factor 2	DEG_SPOP_SBC_1	312:316	PLSSS	SPOP	0.9872	More...
Q8N9Z9	Lamin tail domain-containing protein 1	DEG_SPOP_SBC_1	35:39	PLSSS	SPOP	0.8742	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	114:118	PLSSS	SPOP	0.9937	More...

Showing 1 to 25 of 59 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSSS

Degron related mutations and impact score

Drug responses associated with SH3KBP1 mutations

All proteins holding degron of PLSSS