DegronMD - Q9UBC0(ONECUT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R409S	TCGA-21-1070	LUSC	TCGA	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.3056
p.R409S	DO27088	LUSC	ICGC	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.3056
p.A173S	TCGA-90-A4ED	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1111
p.A173S	TCGA-HF-A5NB	STAD	TCGA	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1111
p.A173S	DO45482	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1111
p.A173S	DO50127	STAD	ICGC	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1111
p.D446Y	TCGA-A5-A0G9	UCEC	TCGA	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	427:440	Mutation rewiring degron network	0.1667
p.D446Y	DO42304	UCEC	ICGC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	427:440	Mutation rewiring degron network	0.1667
p.R409H	TCGA-BR-8081	STAD	TCGA	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.3056
p.R409H	DO38795	STAD	ICGC	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.3056
p.R398Q	TCGA-BR-8081	STAD	TCGA	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.1667
p.R398Q	TCGA-D9-A4Z3	SKCM	TCGA	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.1667
p.R398Q	DO47555	SKCM	ICGC	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.1667
p.R398Q	DO38795	STAD	ICGC	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.1667
p.R409C	TCGA-CK-4951	COAD	TCGA	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.3056
p.R409C	DO10582	COAD	ICGC	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.3056
p.R409C	SIDM00190	Melanoma	GDSC	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.3056
p.R409C	ACH-002097	Skin Cancer	CCLE	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.3056
p.R409C	CP66-MEL	skin	COSMIC	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.3056
p.M175I	TCGA-CN-6010	HNSC	TCGA	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1667
p.M175I	DO14766	HNSC	ICGC	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1667
p.S449N	TCGA-D1-A15X	UCEC	TCGA	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	427:440	Mutation rewiring degron network	0.0833
p.S449N	DO43274	UCEC	ICGC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	427:440	Mutation rewiring degron network	0.0833
p.K443R	TCGA-DI-A1BU	UCEC	TCGA	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	427:440	Mutation substituting flanking lysine	0.3611
p.K443R	DO42023	UCEC	ICGC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	427:440	Mutation substituting flanking lysine	0.3611
p.T417A	TCGA-DI-A1BU	UCEC	TCGA	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.0833
p.T417A	TCGA-DI-A1BU	UCEC	TCGA	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	427:440	Mutation rewiring degron network	0.0556
p.T417A	DO42023	UCEC	ICGC	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.0833
p.T417A	DO42023	UCEC	ICGC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	427:440	Mutation rewiring degron network	0.0556
p.G174V	TCGA-E6-A2P9	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1389
p.G174V	DO43714	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1389
p.R397H	TCGA-F7-A620	HNSC	TCGA	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.1389
p.R397H	DO50355	ESAD	ICGC	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.1389
p.R397H	DO44445	HNSC	ICGC	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.1389
p.R397C	TCGA-FI-A2D5	UCEC	TCGA	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.1389
p.R397C	DO232224	PBCA	ICGC	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.1389
p.R397C	DO41331	UCEC	ICGC	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.1389
p.R397C	ACH-000328	Brain Cancer	CCLE	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.1389
p.G186S	TCGA-KK-A8II	PRAD	TCGA	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.3056
p.G186S	DO219335	PRAD	ICGC	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.3056
p.G186S	SIDM00181	Bladder Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.3056
p.G186S	SIDM01646	Non-Cancerous	GDSC	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.3056
p.G186S	ACH-002358	Non-Cancerous	CCLE	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.3056
p.K405N	DO233898	GACA	ICGC	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation altering degron motif	0.6918
p.D446E	DO229035	LICA	ICGC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	427:440	Mutation rewiring degron network	0.1667
p.W444R	DO23416	LINC	ICGC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	427:440	Mutation rewiring degron network	0.2222
p.E447K	DO231016	LUSC	ICGC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	427:440	Mutation rewiring degron network	0.1389
p.G188D	DO229253	THCA	ICGC	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.25
p.S430I	SIDM02050	Colorectal Carcinoma	GDSC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	427:440	Mutation altering degron motif	0.7341
p.A402T	SIDM02039	Colorectal Carcinoma	GDSC	FKENK	DEG_APCC_KENBOX_2	404:408	Mutation rewiring degron network	0.2778
p.G174S	SIDM00427	Ewing's Sarcoma	GDSC	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1389
p.G174S	RH-1	soft tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1389
p.G176D	SIDM00789	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1944
p.G176D	ACH-000997	Colon/Colorectal Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1944
p.G176D	ACH-001061	Colon/Colorectal Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1944
p.G176D	HCT-15	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1944
p.F432L	SIDM01228	Melanoma	GDSC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	427:440	Mutation altering degron motif	0.6981
p.F432L	ACH-001024	Skin Cancer	CCLE	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	427:440	Mutation altering degron motif	0.6981
p.F432L	CHL-1	skin	COSMIC	STVSNFFMNARRRS	DEG_CRL4_CDT2_1	427:440	Mutation altering degron motif	0.6981
p.S184G	Daudi	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.6993

Kaplan plot for ONECUT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ONECUT1

UniProt ID: Q9UBC0

Entrez ID: 3175

Protein name: Hepatocyte nuclear factor 6 (HNF-6) (One cut domain family member 1) (One cut homeobox 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ONECUT1 in