DegronMD

Uniprot ID: Q9UBC0

Source protein: Hepatocyte nuclear factor 6

Source gene: ONECUT1

Class: DEG_APCC_KENBOX_2

Location: 404:408

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7531

ASA_SCORE: 104.26

COIL: 0.5962

CONS_SCORE: 0.9149

DSS_SCORE: 0.4274

HELIX: 0.402

FCONS_SCORE: 1.0501

RIG_SCORE: 0.7873

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R409S	TCGA-21-1070	LUSC	TCGA	FKENK	DEG_APCC_KENBOX_2	0.3056
p.R409S	DO27088	LUSC	ICGC	FKENK	DEG_APCC_KENBOX_2	0.3056
p.R409H	TCGA-BR-8081	STAD	TCGA	FKENK	DEG_APCC_KENBOX_2	0.3056
p.R409H	DO38795	STAD	ICGC	FKENK	DEG_APCC_KENBOX_2	0.3056
p.R398Q	TCGA-BR-8081	STAD	TCGA	FKENK	DEG_APCC_KENBOX_2	0.1667
p.R398Q	TCGA-D9-A4Z3	SKCM	TCGA	FKENK	DEG_APCC_KENBOX_2	0.1667
p.R398Q	DO47555	SKCM	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1667
p.R398Q	DO38795	STAD	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1667
p.R409C	TCGA-CK-4951	COAD	TCGA	FKENK	DEG_APCC_KENBOX_2	0.3056
p.R409C	DO10582	COAD	ICGC	FKENK	DEG_APCC_KENBOX_2	0.3056
p.R409C	SIDM00190	Melanoma	GDSC	FKENK	DEG_APCC_KENBOX_2	0.3056
p.R409C	ACH-002097	Skin Cancer	CCLE	FKENK	DEG_APCC_KENBOX_2	0.3056
p.R409C	CP66-MEL	skin	COSMIC	FKENK	DEG_APCC_KENBOX_2	0.3056
p.T417A	TCGA-DI-A1BU	UCEC	TCGA	FKENK	DEG_APCC_KENBOX_2	0.0833
p.T417A	DO42023	UCEC	ICGC	FKENK	DEG_APCC_KENBOX_2	0.0833
p.R397H	TCGA-F7-A620	HNSC	TCGA	FKENK	DEG_APCC_KENBOX_2	0.1389
p.R397H	DO50355	ESAD	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1389
p.R397H	DO44445	HNSC	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1389
p.R397C	TCGA-FI-A2D5	UCEC	TCGA	FKENK	DEG_APCC_KENBOX_2	0.1389
p.R397C	DO232224	PBCA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1389
p.R397C	DO41331	UCEC	ICGC	FKENK	DEG_APCC_KENBOX_2	0.1389
p.R397C	ACH-000328	Brain Cancer	CCLE	FKENK	DEG_APCC_KENBOX_2	0.1389
p.K405N	DO233898	GACA	ICGC	FKENK	DEG_APCC_KENBOX_2	0.6918
p.A402T	SIDM02039	Colorectal Carcinoma	GDSC	FKENK	DEG_APCC_KENBOX_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons