DegronMD - B2RTY4(MYO9A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1300S	TCGA-05-5425	LUAD	TCGA	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.1389
p.P1300S	TCGA-EB-A3Y7	SKCM	TCGA	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.1389
p.P1300S	TCGA-EB-A5UM	SKCM	TCGA	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.1389
p.P1300S	TCGA-EE-A3AB	SKCM	TCGA	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.1389
p.F1822C	TCGA-24-1845	OV	TCGA	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation altering degron motif	0.5996
p.R771Q	TCGA-2Y-A9H9	LIHC	TCGA	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.25
p.T1602I	TCGA-59-2349	OV	TCGA	VTVFFE	LIG_APCC_ABBA_1	1601:1606	Mutation altering degron motif	0.5966
p.R1834H	TCGA-A5-A0G2	UCEC	TCGA	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.1111
p.R1834H	SIDM02050	Colorectal Carcinoma	GDSC	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.1111
p.R1834H	SIDM00223	Small Cell Lung Carcinoma	GDSC	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.1111
p.R1834H	ACH-002144	Lung Cancer	CCLE	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.1111
p.R1834H	IST-SL1	lung	COSMIC	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.1111
p.G1609R	TCGA-A8-A09Z	BRCA	TCGA	VTVFFE	LIG_APCC_ABBA_1	1601:1606	Mutation rewiring degron network	0.25
p.N791K	TCGA-AG-A002	READ	TCGA	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.0833
p.N791K	TCGA-EI-6917	READ	TCGA	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.0833
p.F1604V	TCGA-AP-A056	UCEC	TCGA	VTVFFE	LIG_APCC_ABBA_1	1601:1606	Mutation altering degron motif	0.7068
p.R1304C	TCGA-AP-A0LM	UCEC	TCGA	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.25
p.R1304C	TCGA-CA-6717	COAD	TCGA	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.25
p.P1611T	TCGA-AX-A1CE	UCEC	TCGA	VTVFFE	LIG_APCC_ABBA_1	1601:1606	Mutation rewiring degron network	0.1944
p.S1591F	TCGA-BR-8369	STAD	TCGA	VTVFFE	LIG_APCC_ABBA_1	1601:1606	Mutation rewiring degron network	0.0556
p.P1830S	TCGA-D3-A51N	SKCM	TCGA	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.2222
p.I769V	TCGA-DI-A1BU	UCEC	TCGA	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.1944
p.S779C	TCGA-DR-A0ZM	CESC	TCGA	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation altering degron motif	0.643
p.V1601F	TCGA-ER-A19P	SKCM	TCGA	VTVFFE	LIG_APCC_ABBA_1	1601:1606	Mutation altering degron motif	0.5957
p.P1798S	TCGA-IH-A3EA	SKCM	TCGA	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.1111
p.G1816C	TCGA-NJ-A4YQ	LUAD	TCGA	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.1667
p.G1816C	TCGA-NJ-A4YQ	LUAD	TCGA	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.1944
p.P1300L	TCGA-WE-A8ZN	SKCM	TCGA	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.1389
p.P1300L	ACH-001329	Brain Cancer	CCLE	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.1389
p.Q1796E	TCGA-XF-A9SH	BLCA	TCGA	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.0556
p.R1815C	DO1221	BRCA	ICGC	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.1389
p.R1815C	DO1221	BRCA	ICGC	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.2222
p.R1817Q	DO222798	COCA	ICGC	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.1944
p.R1817Q	DO222798	COCA	ICGC	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.1667
p.S1810C	DO234369	ESAD	ICGC	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation altering degron motif	0.7541
p.K1816R	DO233230	GACA	ICGC	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.1667
p.K1816R	DO233230	GACA	ICGC	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.1944
p.H1830N	DO228948	LICA	ICGC	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.2222
p.R1815S	DO228952	LICA	ICGC	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.1389
p.R1815S	DO228952	LICA	ICGC	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.2222
p.R1815S	DO229018	LICA	ICGC	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.1389
p.R1815S	DO229018	LICA	ICGC	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.2222
p.Q773K	DO229018	LICA	ICGC	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.3056
p.F1803L	DO229034	LICA	ICGC	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.25
p.S1602C	DO44950	LIHC	ICGC	VTVFFE	LIG_APCC_ABBA_1	1601:1606	Mutation altering degron motif	0.7541
p.G1797C	DO218944	LUAD	ICGC	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.0833
p.F1803C	DO29920	OV	ICGC	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.25
p.Q1594L	DO46792	PRAD	ICGC	VTVFFE	LIG_APCC_ABBA_1	1601:1606	Mutation rewiring degron network	0.1389
p.N772K	DO36881	READ	ICGC	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.2778
p.P1811S	DO47274	SKCM	ICGC	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation altering degron motif	0.6752
p.R788C	DO37951	SKCM	ICGC	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.1667
p.L1325V	DO48547	STAD	ICGC	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.0556
p.L1314P	DO48547	STAD	ICGC	STELVPEGL	DEG_COP1_1	1307:1315	Mutation altering degron motif	0.7582
p.I787V	DO47953	STAD	ICGC	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.1944
p.E770K	DO229268	THCA	ICGC	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.2222
p.P1592T	DO42280	UCEC	ICGC	VTVFFE	LIG_APCC_ABBA_1	1601:1606	Mutation rewiring degron network	0.0833
p.V1598I	DO42600	UCEC	ICGC	VTVFFE	LIG_APCC_ABBA_1	1601:1606	Mutation rewiring degron network	0.25
p.R1815H	DO41235	UCEC	ICGC	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.1389
p.R1815H	DO41235	UCEC	ICGC	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.2222
p.R1819W	SIDM00958	Chronic Myelogenous Leukemia	GDSC	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.25
p.R1819W	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.1111
p.R1819W	ACH-000920	Leukemia	CCLE	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.25
p.R1819W	ACH-000920	Leukemia	CCLE	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.1111
p.R1819W	ACH-001495	Endometrial/Uterine Cancer	CCLE	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.25
p.R1819W	ACH-001495	Endometrial/Uterine Cancer	CCLE	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.1111
p.R1819W	CML-T1	haematopoietic and lymphoid tissue	COSMIC	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.25
p.R1819W	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.1111
p.G1816S	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.1667
p.G1816S	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.1944
p.G1816S	ACH-000392	Lung Cancer	CCLE	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.1667
p.G1816S	ACH-000392	Lung Cancer	CCLE	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.1944
p.G1816S	Calu-3	lung	COSMIC	FKENK	DEG_APCC_KENBOX_2	1822:1826	Mutation rewiring degron network	0.1667
p.G1816S	Calu-3	lung	COSMIC	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.1944
p.R1319Q	SIDM00433	T-Lymphoblastic Leukemia	GDSC	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.2222
p.R1319Q	ACH-000795	Leukemia	CCLE	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.2222
p.R1319Q	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.2222
p.R775T	SIDM00501	Oral Cavity Carcinoma	GDSC	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation altering degron motif	0.7876
p.R775T	ACH-001332	Head and Neck Cancer	CCLE	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation altering degron motif	0.7876
p.R775T	BICR78	upper aerodigestive tract	COSMIC	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation altering degron motif	0.7876
p.D1323H	SIDM00472	Ovarian Carcinoma	GDSC	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.1111
p.D1323H	ACH-001630	Ovarian Cancer	CCLE	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.1111
p.D1323H	ACH-001632	Ovarian Cancer	CCLE	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.1111
p.D1323H	PEO1	ovary	COSMIC	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1319W	SIDM00244	Neuroblastoma	GDSC	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.2222
p.R1319W	NB69	autonomic ganglia	COSMIC	STELVPEGL	DEG_COP1_1	1307:1315	Mutation rewiring degron network	0.2222
p.D1598N	SIDM00971	Breast Carcinoma	GDSC	VTVFFE	LIG_APCC_ABBA_1	1601:1606	Mutation rewiring degron network	0.25
p.D1598N	ZR-75-30	breast	COSMIC	VTVFFE	LIG_APCC_ABBA_1	1601:1606	Mutation rewiring degron network	0.25
p.M784L	SIDM00105	Ovarian Carcinoma	GDSC	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.2778
p.M784L	OVCAR-3	ovary	COSMIC	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.2778
p.V1603M	SIDM00438	B-Lymphoblastic Leukemia	GDSC	VTVFFE	LIG_APCC_ABBA_1	1601:1606	Mutation altering degron motif	0.6097
p.V1603M	MN-60	haematopoietic and lymphoid tissue	COSMIC	VTVFFE	LIG_APCC_ABBA_1	1601:1606	Mutation altering degron motif	0.6097
p.A786S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.2222
p.A786S	ACH-001127	Leukemia	CCLE	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.2222
p.A786S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.2222
p.N773I	SIDM00638	Cervical Carcinoma	GDSC	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.3056
p.N773I	ACH-001360	Cervical Cancer	CCLE	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.3056
p.N773I	MS751	cervix	COSMIC	PRTPLSDLQ	DEG_APCC_DBOX_1	774:782	Mutation rewiring degron network	0.3056
p.A1803V	ACH-000960	Leukemia	CCLE	PTPPLS	DEG_SCF_FBW7_1	1806:1811	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYO9A

UniProt ID: B2RTY4

Entrez ID: 4649

Protein name: Unconventional myosin-IXa (Unconventional myosin-9a)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYO9A in