DegronMD

Uniprot ID: B2RTY4

Source protein: Unconventional myosin-IXa

Source gene: MYO9A

Class: LIG_APCC_ABBA_1

Location: 1601:1606

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.975

ASA_SCORE: 79.8167

COIL: 0.6247

CONS_SCORE: 0.3139

DSS_SCORE: 0.5422

HELIX: 0.0978

FCONS_SCORE: 1.0356

RIG_SCORE: 0.7832

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1602I	TCGA-59-2349	OV	TCGA	VTVFFE	LIG_APCC_ABBA_1	0.5966
p.G1609R	TCGA-A8-A09Z	BRCA	TCGA	VTVFFE	LIG_APCC_ABBA_1	0.25
p.F1604V	TCGA-AP-A056	UCEC	TCGA	VTVFFE	LIG_APCC_ABBA_1	0.7068
p.P1611T	TCGA-AX-A1CE	UCEC	TCGA	VTVFFE	LIG_APCC_ABBA_1	0.1944
p.S1591F	TCGA-BR-8369	STAD	TCGA	VTVFFE	LIG_APCC_ABBA_1	0.0556
p.V1601F	TCGA-ER-A19P	SKCM	TCGA	VTVFFE	LIG_APCC_ABBA_1	0.5957
p.S1602C	DO44950	LIHC	ICGC	VTVFFE	LIG_APCC_ABBA_1	0.7541
p.Q1594L	DO46792	PRAD	ICGC	VTVFFE	LIG_APCC_ABBA_1	0.1389
p.P1592T	DO42280	UCEC	ICGC	VTVFFE	LIG_APCC_ABBA_1	0.0833
p.V1598I	DO42600	UCEC	ICGC	VTVFFE	LIG_APCC_ABBA_1	0.25
p.D1598N	SIDM00971	Breast Carcinoma	GDSC	VTVFFE	LIG_APCC_ABBA_1	0.25
p.D1598N	ZR-75-30	breast	COSMIC	VTVFFE	LIG_APCC_ABBA_1	0.25
p.V1603M	SIDM00438	B-Lymphoblastic Leukemia	GDSC	VTVFFE	LIG_APCC_ABBA_1	0.6097
p.V1603M	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	VTVFFE	LIG_APCC_ABBA_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
B2RTY4	Unconventional myosin-IXa	LIG_APCC_ABBA_1	1601:1606	VTVFFE	APC,CDC20,FZR1	0.975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons